Actively Recruiting
Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables
Led by Friedrich-Alexander-Universität Erlangen-Nürnberg · Updated on 2026-04-09
25
Participants Needed
1
Research Sites
600 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to learn about the effects of sacral neuromodulation in pediatric patients with gastrointestinal motility disorders. By combining advanced neuroimaging, patient-specific biophysical modeling, electrophysiological characterization, and clinical translation, the SMART-GUT project establishes a comprehensive framework to systematically investigate neuromodulation in this pediatric population. This integrative approach enables a direct link between mechanism, targeting, and clinical outcome.
CONDITIONS
Official Title
Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Informed consent from patient and caregiver
- Diagnosis of gastrointestinal motility disorder regardless of underlying disease
- No mechanical obstruction in gastrointestinal tract
- Age between 3 and 18 years
You will not qualify if you...
- Pregnancy or breastfeeding
- Reduced kidney or thyroid function
- Use of certain drugs including beta-blockers, antispasmodics, cyclopropane, bisulfite compounds, haloperidol, heroin, meperidine, metamizole, methadone, morphine, nitrofurantoin, opium alkaloids, phenobarbital, phenylbutazone, probenecid, rifamycin
- MRI contraindications
- Need for sedation for MRI
- Inflammatory bowel diseases
- Fractures or anatomical abnormalities in sacral area
- Epilepsy
- Presence of cardiac pacemakers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Pediatric Surgery in the Children's Hospital
Erlangen, Germany, 91054
Actively Recruiting
Research Team
S
Sonja Diez, PD Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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