Actively Recruiting
Improvements in Thyroid Tumor Surgery and the Prognosis, Diagnosis, Recurrence and Metastasis of Patients
Led by Second Affiliated Hospital of Xi'an Jiaotong University · Updated on 2024-06-21
170
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating improved surgical techniques for transthoracic endoscopic thyroidectomy, focusing on whether omitting the cervical linea alba suture can reduce operation time, postoperative pain, and incision complications. The study also aims to collect normal thyroid tissues, benign and malignant tumors, and lymph nodes to better understand the processes involved in the development, spread, and return of thyroid cancer. Participants will undergo either suturing or not suturing the cervical linea alba during minimally invasive thyroid surgery through a breast approach. The study involves collecting tissue samples including thyroid papillary carcinoma, adjacent thyroid tissue, and lymph nodes with or without metastasis. Transcriptome sequencing will be performed on collected tissues to analyze mRNA expression profiles within one month after surgery. During the study, participants will have preoperative assessments including ultrasound, CT scans, thyroid function tests, and fine-needle biopsies. Researchers will monitor outcomes such as postoperative neck swelling and pain within one week after surgery and analyze tissue gene expression. Participation involves routine clinical diagnosis, treatment, and tissue collection during surgery. The study is expected to last until January 2026 and involves about 200 volunteers.
CONDITIONS
Brief Title
Improvements in Thyroid Tumor Surgery and the Prognosis, Diagnosis, Recurrence and Metastasis of Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing transthoracic endoscopic thyroidectomy via the breast approach
- Postoperative pathology confirms benign or malignant thyroid tumors
- Preoperative thyroid ultrasound or neck CT shows no tumor spread outside the thyroid or distant metastasis
- No contraindications for general anesthesia
- Patients with cosmetic concerns about surgical scars
You will not qualify if you...
- Previous transthoracic endoscopic thyroidectomy
- Postoperative pathology confirms benign or malignant thyroid tumors (if already treated)
- Preoperative thyroid ultrasound or neck CT shows tumor spread outside the thyroid or distant metastasis
- Contraindications to general anesthesia
- No cosmetic requirements for surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and up to 1 week post-surgery
Participants undergo transthoracic endoscopic thyroidectomy via the breast approach with or without suturing the cervical linea alba, and receive immediate post-operative care.
Approximately 1 surgery visit and daily follow-up visits for up to 1 week
Duration - Up to 1 month after surgery
Participants are monitored for short-term outcomes including neck edema and pain and tissue samples are collected for transcriptome sequencing analyses.
1 to 2 visits within one month post-surgery
Trial Site Locations
Total: 1 location
1
Xi'an Jiaotong University Second Affiliated Hospital
Xi'an, Shaanxi, China, 710049
Actively Recruiting
Research Team
Z
Zhidong Wang, Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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