Actively Recruiting
Telehealth Cognitive Training Combined with Aerobic Exercise to Improve Thinking Skills After a First Episode of Schizophrenia
Led by University of California, Los Angeles · Updated on 2026-08-04
100
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
This research is focused on individuals who have experienced a first episode of schizophrenia or related disorders such as schizoaffective or schizophreniform disorder. The study aims to evaluate the effects of combining aerobic exercise with cognitive training on improving cognitive deficits, brain neuroplasticity, and motivation. The trial is designed as a 12-month randomized controlled study delivered via telehealth to maximize accessibility and feasibility outside academic settings. Participants will be randomly assigned to one of two groups one receiving combined cognitive training and aerobic exercise, and the other receiving cognitive training plus participation in a Healthy Living Group. The aerobic exercise program involves moderate-intensity activities totaling 150 minutes per week, including group and individual sessions, while cognitive training is conducted in group videoconference sessions with specific neurocognitive and social cognitive training components. The Healthy Living Group offers educational sessions on wellness and life skills. Additional support such as wearable fitness trackers, motivational online platforms, and personalized text reminders will be provided to enhance engagement. During the study, participants will attend regular telehealth sessions for cognitive training and either exercise or healthy living education. Researchers will monitor changes in cognition using standard cognitive tests, measure serum levels of brain-derived neurotrophic factor Mature BDNF as an indicator of neuroplasticity, and assess motivation and attendance at exercise sessions. The study will track these outcomes at multiple time points, including 2 weeks, 3 months, and 6 months. Participation involves ongoing videoconference group activities, motivational support, and assessments to evaluate the impact of interventions on cognitive and functional outcomes over one year.
CONDITIONS
Brief Title
Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode
Research Team
D
Danielle Denenny, PhD
A
Alma Munguia
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