Actively Recruiting
Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant
Led by University of Nebraska · Updated on 2025-07-23
88
Participants Needed
1
Research Sites
293 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cancer and treatment-related cognitive changes, such as thinking or remembering, hinder resumption of normal routine and roles and worsen quality of life. Older adults undergoing hematopoietic cell transplantation (HCT) are at high-risk for cognitive impairment. Age is a risk factor for Alzheimer's Dementia (AD) and the hematological malignancies leading to HCT. There are shared mechanisms and interactions between AD and cancer-related cognitive decline (CRCD). Physical activity improves cognitive function in older adults and survivors of other cancers. This study hypothesizes that increasing physical activity can also improve cognitive function in this vulnerable population. The study has two goals. The first is to adapt and test an evidence-based physical activity intervention, The Community Health Activities Model Program for Seniors II (CHAMPS II), in the HCT setting for adults 55 years and older. This will be done using semi-structured interview of up to 10 patients who have experienced the HCT process within the last 3 to 6 months with HCT care-team partners. The second goal will explore the prevalence and impact of AD-neuropathology and inflammation on cancer-related cognitive decline (CRCD) in older adults undergoing HCT.
CONDITIONS
Official Title
Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years and older (Arm 1) or 55 years and older (Arms 2 and 3)
- Diagnosis of hematological malignancy
- Received autologous or allogeneic hematopoietic cell transplantation within the prior 3-6 months (Arm 1) or planned to receive HCT (Arms 2 and 3)
- Able to walk 4 meters as part of the Short Physical Performance Battery (with or without assistance) (Arms 2 and 3)
- Able to speak and read English
- Provided written informed consent
- For Arm 3 participants, willingness to be randomized to initiate physical activity intervention either before HCT or after Day 180 post-HCT
- Care-partners aged 19 years and older, able to speak and read English, able to walk 4 meters (with or without assistance), and medically cleared for light to moderate physical activity
- Transplant team members aged 19 years and older, able to speak and read English
You will not qualify if you...
- Development of chest pain, severe shortness of breath, or other safety concerns during physical performance measures
- Not cleared to participate in exercise by a physician
- Medical history requiring cardiologist clearance for exercise, including recent myocardial infarction (past 3 months), unstable angina, uncontrolled arrhythmias, 3rd degree heart block, acute congestive heart failure or ejection fraction <30%, or significant aortic stenosis
- Medical history requiring surgeon clearance for exercise, including hip fracture, hip or knee replacement, or spinal surgery in the past 3 months
- Other medical, psychiatric, or behavioral factors that may interfere with participation or ability to follow the intervention or control condition
- For Arm 3 voluntary biomarker and MRI measures: history of severe traumatic brain injury or brain abnormalities, major stroke with residual deficits, relapsing-remitting multiple sclerosis, or active moderate to severe psychiatric symptoms due to primary psychiatric disorder
- No exclusion criteria for care-partners or transplant team members beyond the above medical requirements
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
Research Team
M
Marcia M Free, BSN
CONTACT
T
Thuy Koll, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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