Physical Activity Program to Improve Thinking and Memory in Older Adults Undergoing Stem Cell Transplant for Blood Cancers

What this Trial Is About

Older adults undergoing hematopoietic cell transplantation HCT for hematologic malignancies are at high risk for cognitive decline, which negatively impacts their quality of life and ability to resume daily routines. This research focuses on adults aged 55 and older, studying the effects of physical activity on improving cognitive function in this vulnerable group. The study also investigates the presence and impact of Alzheimers disease-related neuropathology and inflammation on cancer-related cognitive decline in this population. Participants will engage in an adapted version of the Community Health Activities Model Program for Seniors II CHAMPS-II, a tailored physical activity program designed for sedentary older adults with multiple chronic health conditions. The program includes supervised and unsupervised exercise sessions, counseling, and telephone support, focusing on walking and exercises for flexibility, strength, and balance. Some participants will provide feedback on intervention materials through interviews, while others will be randomized to immediate or delayed intervention groups to assess the programs impact. During the study, participants will undergo cognitive testing at baseline and after 12 weeks, including assessments of executive function and working memory using tests such as Trails A and B, Controlled Oral Word Association Test, and Hopkins Verbal Learning Test-Revised. Additional evaluations include global cognitive function and subjective memory questionnaires. Researchers will monitor implementation, gather participant feedback, and explore brain imaging and biomarker data to better understand cognitive changes and their underlying mechanisms in older adults undergoing HCT.

Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant