Actively Recruiting
Improving Cognitive Rehabilitation Outcomes
Led by VA Office of Research and Development · Updated on 2026-04-24
144
Participants Needed
2
Research Sites
234 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
P
Portland VA Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Posttraumatic stress disorder (PTSD) and mild TBI (mTBI) frequently co-occur in post-9/11 Veterans, and together are associated with worse cognitive performance, mental health, everyday functioning, community integration, quality of life, and treatment response than either condition alone. Additional comorbidities, such as depression and sleep disturbance, are common and further exacerbate these problems. The investigators will investigate Compensatory Cognitive Training (CCT) and Morning Bright Light Therapy (MBLT) vs Negative Ion Generator (ION), to directly target cognition, depression, and sleep disturbance and to improve CCT-associated rehabilitation outcomes. The investigator's randomized controlled trial in 144 Veterans with mTBI+PTSD across two VA sites will compare cognition, functioning, and other secondary outcomes following CCT+MBLT vs. CCT+ION. This study addresses the significant gap in services and evidence-based treatments for Veterans with mTBI+PTSD.
CONDITIONS
Official Title
Improving Cognitive Rehabilitation Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Post 9/11 Veterans enrolled at VA San Diego or VA Portland
- Ability to provide informed consent
- Living independently
- History of mild traumatic brain injury confirmed by OSU-TBI
- Current diagnosis of PTSD confirmed by CAPS-5
- Current cognitive concerns about thinking, attention, or memory
- Current concern regarding depression and/or sleep disturbance defined by PHQ-9 score of 5 and/or ISI score of 8, including at least moderate difficulty falling asleep, staying asleep, or waking too early
You will not qualify if you...
- Current substance use disorder with less than 30 days abstinence
- History of primary psychotic disorder
- History of moderate to severe traumatic brain injury with loss of consciousness longer than 30 minutes
- History of macular degeneration or bipolar disorder (contraindicated for bright light therapy)
- Working night or swing shift schedules
- Untreated obstructive sleep apnea by self-report or STOP-BANG score of 5
- Current engagement in bright light therapy
- Auditory or visual impairments that prevent participation in assessments or treatments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States, 92161-0002
Actively Recruiting
2
VA Portland Health Care System, Portland, OR
Portland, Oregon, United States, 97207-2964
Actively Recruiting
Research Team
M
Michelle Z Schy
CONTACT
J
Janae R Wyckoff
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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