Actively Recruiting
Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment
Led by Wake Forest University Health Sciences · Updated on 2026-03-20
110
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research focuses on patients with stage I-IV Hodgkin's or non-Hodgkin's lymphoma and stage I-III breast cancer undergoing potentially heart-impacting cancer treatments. It aims to compare two approaches: a physical activity program and a series of educational health workshops, to see which better preserves exercise ability, heart function, brain activity such as memory, and overall quality of life during cancer treatment. Participants are randomly assigned to one of two groups. The first group attends health workshops covering nutrition, stress management, sleep, and healthy lifestyle tips, with some stretching exercises, meeting weekly at first and then less frequently over six months. The second group follows a physical activity program involving one to two training sessions weekly plus home sessions guided by the Trainerize app, including warm-up, strength training, aerobic exercise, and cool down. Throughout the study, participants undergo tests like cardiopulmonary exercise testing and MRI scans of the heart, and they complete questionnaires on quality of life, fatigue, cognitive function, and physical activity. Blood samples are taken to monitor health markers. The main measurement is the change in peak oxygen consumption after six months, with additional assessments at three and six months. The study lasts six months, with ongoing evaluations to understand how each intervention impacts physical and cognitive health during cancer treatment.
CONDITIONS
Brief Title
Improving Exercise Capacity With a Tailored Physical Activity Intervention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals aged 18 to 85 years
- Diagnosed with stage I-IV Hodgkin's or non-Hodgkin's lymphoma or stage I-III breast cancer
- Expected to receive anthracycline-based chemotherapy or other potentially cardiotoxic cancer therapies, immunotherapies, or radiation within 8 weeks of completion
- Ability to speak and understand English
- Ability to walk at least 2 city blocks (about 0.2 miles) on a flat surface
- Expected survival beyond 6 months
- Must have an assistant to help with home-based testing activities
You will not qualify if you...
- Uncontrolled hypertension with systolic blood pressure over 190 mm Hg or diastolic blood pressure over 100 mm Hg
- Recent history of alcohol or drug abuse, inflammatory conditions like lupus or inflammatory bowel disease, or other medical conditions compromising safety or study completion unless approved
- Contraindications to MRI such as certain metal implants or electronic devices unless approved
- Pregnancy
- Unstable angina
- Contraindications for exercise training or testing
- Inability to exercise on a treadmill or stationary cycle
- Significant ventricular arrhythmias over 20 PVCs/min
- Atrial fibrillation with uncontrolled ventricular response
- Recent acute myocardial infarction within 28 days
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 months
Participants engage in one of two interventions: a tailored physical activity program with 1-2 exercise sessions per week using the Trainerize application, or weekly to monthly health workshops over 6 months.
1 to 2 exercise sessions per week or 12 health workshop sessions over 6 months
Duration - 6 months
Participants complete physical tests, MRI scans, blood draws, and questionnaires to measure exercise capacity, heart function, cognitive and physical function, and quality of life at baseline, 3 months, and 6 months.
3 assessment visits (baseline, 3 months, and 6 months)
Trial Site Locations
Total: 2 locations
1
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
2
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
S
Study Coordinator
P
Pamela J. Grizzard
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here