Actively Recruiting
Improving Exercise Capacity With a Tailored Physical Activity Intervention
Led by Wake Forest University Health Sciences · Updated on 2026-03-20
110
Participants Needed
2
Research Sites
182 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research is to test whether participating in either a physical activity intervention or a series of educational classes will help to preserve exercise capability, heart function, brain-based activities (like memory), and quality of life. Participants will be randomized to 1 of 2 pathways: * First pathway consists of organized health workshops. These workshops are intended to provide information on topics such as proper nutrition, management of stress, sleep practices, and emphasis on a healthy lifestyle that may help the participants through cancer treatment. This pathway will also test whether stretching may help participants through cancer treatment. * Second pathway participants will take part in some unsupervised and some potentially supervised moderate activity sessions each week throughout participants' cancer treatment to take place either remotely or in person, depending on availability of facilities at the time visits are scheduled.
CONDITIONS
Official Title
Improving Exercise Capacity With a Tailored Physical Activity Intervention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals aged 18 to 85 years
- Diagnosed with stage I-IV Hodgkin's or non-Hodgkin's lymphoma or stage I-III breast cancer
- Expected to receive anthracycline-based chemotherapy or other potentially cardiotoxic cancer therapies, immunotherapies, or radiation within 8 weeks of completion
- Ability to speak and understand English
- Capacity to walk at least 2 city blocks (~0.2 miles) on a flat surface
- Expected survival beyond 6 months
- Must have an assistant to help perform home-based testing activities
You will not qualify if you...
- Uncontrolled hypertension (systolic >190 mm Hg or diastolic >100 mm Hg)
- Recent history of alcohol or drug abuse, inflammatory conditions like lupus or inflammatory bowel disease, or other medical conditions compromising safety or study completion unless approved by physician and Principal Investigator
- Contraindications to MRI such as cerebral aneurysm clips, implanted electronic devices, unless approved
- Pregnancy
- Unstable angina
- Contraindication for exercise training or testing
- Inability to exercise on a treadmill or stationary cycle
- Significant ventricular arrhythmias (>20 PVCs/min)
- Atrial fibrillation with uncontrolled ventricular response
- Acute myocardial infarction within past 28 days
- Inability to provide informed consent
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
2
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
S
Study Coordinator
CONTACT
P
Pamela J. Grizzard
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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