Actively Recruiting
Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection
Led by Trustees of Dartmouth College · Updated on 2025-12-03
6000
Participants Needed
2
Research Sites
260 weeks
Total Duration
On this page
Sponsors
T
Trustees of Dartmouth College
Lead Sponsor
M
Mayo Clinic
Collaborating Sponsor
AI-Summary
What this Trial Is About
Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resistance and virulence traits. The investigators have proven that a multifaceted program involving improved basic perioperative preventive measures can generate substantial reductions in S. aureus transmission and significant reductions in SSIs (88% reduction as compared to usual care). In this study, the investigators aim to examine the relative effectiveness of each component of this program in controlling ESKAPE transmission and reducing SSIs and to identify an optimal implementation strategy for national dissemination. Randomization occurs at the site level, and sites adopt preventative programs. This work will improve perioperative patient safety for the 51 million patients who undergo surgery each year.
CONDITIONS
Official Title
Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Operating room conducting orthopedic total joint and spine procedures
- Surgeons performing orthopedic total joint or spine surgeries
- Elective patients undergoing orthopedic total joint and spine surgeries
- Sites enrolling 250 patients (125 case pairs) per phase for active and sustainability phases (total 6,000 patients)
You will not qualify if you...
- Medical centers currently enrolling patients in another bacterial transmission or infection prevention trial
- Patients not requiring anesthesia or placement of a peripheral intravenous catheter
- Patients without an incision or who do not provide informed written consent
- Allergy to chlorhexidine, povidone iodine, or isopropyl alcohol
- ASA health classification status greater than 5
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
2
Trustees of Dartmouth College
Hanover, New Hampshire, United States, 03755
Actively Recruiting
Research Team
J
Jeremiah R Brown, PhD
CONTACT
I
Iben Sullivan, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
4
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