Actively Recruiting
Improving Learning and Memory in Portuguese Patients With Multiple Sclerosis
Led by Centro Hospitalar De São João, E.P.E. · Updated on 2025-02-12
80
Participants Needed
1
Research Sites
190 weeks
Total Duration
On this page
Sponsors
C
Centro Hospitalar De São João, E.P.E.
Lead Sponsor
I
Instituto de Saude Publica da Universidade do Porto
Collaborating Sponsor
AI-Summary
What this Trial Is About
Deficits in memory and learning are common in Multiple Sclerosis, posing significant challenges in patients' daily lives. Cognitive rehabilitation has been shown to be effective in ameliorating these deficits, with programs such as the Modified Story Memory Technique (mSMT). In Portugal, no studies tested the efficacy of memory training programs. We aim to fill that gap by translating and developing mSMT, conducting a randomized double-blind, placebo-control, clinical trial, and, therefore, testing its efficacy through objective measures of cognitive function, and the maintenance of its benefits longitudinally. Patients with documented impairment in new learning abilities will be recruited at Centro Hospitalar Universitario São João, and randomly assigned to a memory retraining group or an active control group. Both groups will undergo baseline, immediate, and long-term follow-up assessments consisting of (1) a neuropsychological comprehensive assessment and (2) self-reported questionnaires regarding symptoms of anxiety, depression, fatigue, quality of life, and sleep. Optional enrollment in pre-post neuroimaging will also allow us to look at changes in the brain.
CONDITIONS
Official Title
Improving Learning and Memory in Portuguese Patients With Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Established diagnosis of Multiple Sclerosis according to McDonald criteria
- Adult native Portuguese speakers
- At least four years of education
- No relapses or steroid use for at least one month
- No neurological history other than MS
- No history of major depressive disorder, schizophrenia, bipolar disorder, or substance use/dependence
- No significant visual problems affecting test participation
- Documented impairment in verbal new learning based on standardized tests
You will not qualify if you...
- Relapse or exacerbation within the past month
- History of head injury, stroke, seizures, or other significant neurological conditions
- Current use of steroids, benzodiazepines, or neuroleptics
- Active diagnosis of major depressive disorder, schizophrenia, or bipolar disorder
- Poor vision, double vision, or involuntary eye movements
- Inability to understand and follow simple to complex instructions
- Normal new learning and memory abilities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centro Hospitalar Universitário de São João
Porto, Portugal, 4200-319
Actively Recruiting
Research Team
M
Márcia França, Master's Degree
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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