Actively Recruiting
Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies
Led by Jia-Rong Wu · Updated on 2026-05-05
328
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
J
Jia-Rong Wu
Lead Sponsor
N
National Institute of Nursing Research (NINR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the proposed intervention, nurses will use easy-to-understand language to coach patients and their care partners to help them work together and build skills to overcome their individual barriers to adherence in order to 1) improve and sustain patient medication adherence; 2) reduce hospitalization; 3) improve quality of life. If effective, this intervention will support long-term medication adherence, thus reducing hospitalizations related to heart failure and quality of life.
CONDITIONS
Official Title
Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of heart failure (either systolic or diastolic)
- Suboptimal medication adherence
- Have a care partner involved in heart failure care
- Willingness to involve care partner in medication taking
- Stable doses of heart failure medications prescribed for at least 3 months
- Responsible for own medication administration
- Willingness to use SimpleMed+ electronic pillbox
- Availability by phone
- Care partners must be unpaid family member, friend, partner, or relation involved at least 3 times a week
- Care partners willing to participate together with the patient
- Care partners must be 18 years or older
You will not qualify if you...
- Cognitive impairment preventing informed consent
- Hospitalization within 3 months before enrollment
- End-stage renal disease or terminal illness with less than 1-year life expectancy
- Psychotic illness
- Current alcohol dependence or substance abuse
- Inability to speak English or other communication barriers
- Received similar self-care intervention in the past year
- Care partners with cognitive impairment
- Care partners with terminal illness
- Non-English speaking care partners or other communication barriers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Jia-Rong Wu
Lexington, Kentucky, United States, 40536
Actively Recruiting
Research Team
J
Jia-Rong Wu, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
4
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