Actively Recruiting
Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
Led by Boston University Charles River Campus · Updated on 2025-09-19
204
Participants Needed
1
Research Sites
232 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the development of drug-free interventions for improving memory in AD and related dementias.
CONDITIONS
Official Title
Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 50 and 100 years
- Diagnosis of mild Alzheimer's disease dementia meeting NIA-AA criteria with specific memory and cognitive impairments
- Diagnosis of mild cognitive impairment due to Alzheimer's disease by NIA-AA criteria
- Healthy controls matched by age, education, and gender with normal cognitive performance
- Current mild depression or anxiety not requiring hospitalization or certain medications allowed
- Allowed medical conditions include hyperlipidemia, hypertension, heart disease, asthma, gastroesophageal reflux, edema, treated hypothyroidism, systemic vascular disease (excluding stroke), dermatological and ophthalmologic disorders
- Allowed medications include selective serotonin reuptake inhibitors, cholinesterase inhibitors (for AD patients), statins, beta blockers, bronchodilators, ACE inhibitors, calcium channel blockers, angiotensin II receptor blockers, antihypertensives, histamine-2 receptor antagonists, proton-pump inhibitors, diuretics, thyroid medications, aspirin, non-narcotic analgesics, antiplatelet agents, vitamins, minerals, topical medications, and eye drops
- Normal or corrected-to-normal vision and color vision
- Nonpregnant
- No metal implants or implanted electronic devices in the head
- No skin sensitivity or claustrophobia
- Ability to understand informed consent and experimental procedures
You will not qualify if you...
- History of stroke or traumatic brain injury
- Other brain or systemic disorders causing permanent cognitive changes
- Significant vision or hearing impairments preventing understanding of consent or study procedures
- Pregnant individuals
- Presence of metal implants or electronic devices in the head
- Skin sensitivity or claustrophobia interfering with procedures
- Unable to understand informed consent or experimental tasks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
677 Beacon St. Room 308
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
R
Robert M. G. Reinhart, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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