Actively Recruiting
Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)
Led by University of Cincinnati · Updated on 2025-12-22
72
Participants Needed
1
Research Sites
222 weeks
Total Duration
On this page
Sponsors
U
University of Cincinnati
Lead Sponsor
U
University of New Mexico
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have undergone acute operative treatment of severe traumatic brain injury.
CONDITIONS
Official Title
Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical indication for emergency craniotomy with dural opening to treat acute traumatic brain injury within 72 hours after trauma
- Age between 18 and 80 years
You will not qualify if you...
- Persistent bilateral non-reactive pupils or other evidence of non-survivable injury
- Decompressive craniectomy to treat refractory intracranial pressure after diffuse injury
- Co-enrollment in another therapeutic traumatic brain injury trial
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Cincinnati
Cincinnati, Ohio, United States, 45267
Actively Recruiting
Research Team
J
Jed A Hartings, PhD
CONTACT
K
Karmen Herzig
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here