Iodine-Based Dual-Energy Computed Tomography After Mechanical Thrombectomy Predicts Secondary Neurologic Decline from Cerebral Edema After Severe Stroke.
William Zimmerman, Melissa Pergakis, Ghasan Ahmad...
https://pubmed.ncbi.nlm.nih.gov/39448427Actively Recruiting
Age: 18Years +
All Genders
ID04189471
Recovery After Cerebral Hemorrhage Improving Outcomes for Patients With Life-Threatening Neurologic Illness
Led by University of Maryland, Baltimore · Updated on 2025-07-01
5000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying life-threatening neurological illnesses treated in a specialized 22-bed NeuroCritical Care Unit (NCCU) to better understand the common pathways that cause brain injury and how complications and treatments may affect recovery. This observational study includes patients with conditions such as massive stroke, various brain hemorrhages, brain tumors, severe seizures, neurological infections, nerve and muscle diseases, and spinal cord disorders. The goal is to gather detailed clinical data to improve knowledge about patient outcomes and injury mechanisms. The study collects extensive data from patients admitted to the NCCU, including medical records, physiological measurements, laboratory tests, and standard diagnostic imaging like CT and MRI. Additionally, blood and cerebrospinal fluid samples may be collected when medically appropriate. Data collection spans both retrospective and prospective periods, starting from January 2012 onward. No experimental treatments are given; patients receive standard ICU care while their information is recorded for research purposes. Participants will have their mental status and neurological function assessed multiple times during hospitalization and at follow-up visits 3 and 12 months after injury. These evaluations include interviews, cognitive tests, and quality of life assessments. Researchers will analyze relationships between clinical variables and long-term outcomes like cognitive function and disability. The study aims to provide valuable insights to guide future care and research in neurocritical illness.
CONDITIONS
Brief Title
Improving Outcomes for Patients With Life-Threatening Neurologic Illness
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of potentially life-threatening neurological illness
- Admitted to Neuro ICU within 14 days of initial injury
- Age 18 years or older
You will not qualify if you...
- Known pre-existing neurological deficits related to a developmental disorder
- Prior severe stroke
- Prior severe dementia
- Prior severe head injury
- Prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) to assess eligibility and obtain consent
Monitoring
Duration - Up to 2 weeks or duration of ICU stay
Participants admitted to the Neuro ICU are observed with collection of clinical data, physiological measurements, laboratory results, and imaging as part of standard ICU care. Mental status assessments are performed several times daily and recorded prospectively in a rigorous, standardized manner.
Continuous monitoring during ICU stay with multiple daily assessments
Follow-up
Duration - Up to 12 months after initial injury
Participants and their caregivers may be asked to return for follow-up evaluations to assess neurological status, disability, cognitive function, emotional status, and quality of life. These evaluations may be conducted in person or by telephone.
Follow-up visits or calls at approximately 2 weeks, 3 months, and 12 months after injury
Trial Site Locations
Total: 1 location
1
University of Maryland Medical Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
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Research Team
G
Gunjan Parikh
M
Mayurapriyan Somalinga
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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