Actively Recruiting
Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo
Led by Wake Forest University Health Sciences · Updated on 2026-02-03
50
Participants Needed
1
Research Sites
410 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
We aim to study the impact of perioperative IV lidocaine on postoperative pain control in patients undergoing paraesophageal hernia repair. This is in the context of an established ERAS protocol. We wish to study the effect of IV Lidocaine on postoperative short and long-term outcomes, including patients' length of stay postoperative mortality, morbidity, and quality of life. We will compare this to our standard pain management.
CONDITIONS
Official Title
Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years and older
- American Society of Anesthesiologists (ASA) physical status of I to III
- Undergoing elective laparoscopic paraesophageal hernia repair, including robotic-assisted laparoscopic cases
- All paraesophageal hernia patients seen in clinic who meet inclusion criteria and are offered enrollment
- Cases converted to open laparotomy or hand-assisted laparoscopy included for intention-to-treat analysis
- Patients with complications classified as Clavien-Dindo class 3 or higher included in complication rate calculations but excluded from postoperative morphine equivalent calculations
You will not qualify if you...
- Patients with end-stage renal disease
- Patients allergic to lidocaine or other amide local anesthetics
- Patients with contraindications to sodium channel blockers
- Patients with psychomotor retardation
- Patients with body mass index greater than 40 mg/kg2
- Patients who used opioid pain medication in the previous week or take daily medication for chronic pain
- Patients with seizure disorder
- Patients with cardiac intraventricular conduction delays, congestive heart failure, or first or second-degree heart conduction blocks
- Patients undergoing planned additional procedures other than paraesophageal hernia repair
- Patients classified as ASA 4 or 5 during preoperative anesthesia visit
- Exclusion may be applied at the discretion of the attending surgeon and anesthesiologist
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Atrium Health - Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
Actively Recruiting
Research Team
G
Greg Scarola
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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