Actively Recruiting
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments (PCS-HBOT Study)
Led by Sunnybrook Health Sciences Centre · Updated on 2026-03-16
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying post COVID-19 condition, a syndrome affecting people who have recovered from COVID-19 but continue to experience symptoms like chronic fatigue, brain fog, stress, or anxiety for at least three months. This condition can seriously affect quality of life. The study aims to explore the feasibility of using hyperbaric oxygen therapy (HBOT) as a treatment for these symptoms and to prepare for a larger clinical trial to evaluate its impact. Participants will receive hyperbaric oxygen therapy using a medical-grade monoplace hyperbaric chamber. The treatment consists of 40 sessions, each lasting 90 minutes at 2 atmospheres, delivered daily from Monday to Friday over about eight weeks. Participants are randomly assigned to start the treatment immediately after referral or after a 60-day delay. The study will follow patients for 12 months from the start of treatment, with regular assessments. During the study, participants will complete questionnaires and undergo assessments at enrollment, at the start of treatment, four weeks after treatment begins, and every two months for a year. Researchers will track recruitment rates, adherence to the treatment protocol, patient satisfaction, and clinical outcomes related to fatigue and quality of life. This will help determine if a larger trial is feasible and effective in assessing HBOT for post COVID-19 symptoms.
CONDITIONS
Brief Title
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Official diagnosis of post COVID-19 condition by a healthcare practitioner
- At least three months since initial COVID-19 infection
- Symptoms lasting more than 12 weeks, including chronic fatigue plus either brain fog or stress/anxiety
You will not qualify if you...
- Medical conditions preventing safe hyperbaric oxygen therapy (e.g., pneumothorax, unstable heart disease)
- History of cognitive difficulties or mental retardation before COVID-19
- History of traumatic brain injury
- Unlikely to comply with follow-up (e.g., no fixed address, plans to move)
- Known pregnancy or planning pregnancy in women of childbearing age
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 8 weeks
Participants receive hyperbaric oxygen therapy (HBOT) treatments consisting of 40 daily sessions (Monday to Friday), each lasting 90 minutes in a medical-grade hyperbaric chamber, overseen by specialist physicians and technologists.
Daily visits Monday to Friday for up to 8 weeks
Duration - Up to 12 months after start of treatment
Participants complete assessments including subjective questionnaires on satisfaction and symptom evaluation at multiple time points after treatment, continuing up to 12 months from the start of treatment.
Assessments at 4 weeks after treatment start and every 2 months up to 12 months
Trial Site Locations
Total: 1 location
1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5
Actively Recruiting
Research Team
F
Fahad Alam, MD
L
Lilia Kaustov, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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