Actively Recruiting
ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions
Led by Montreal Heart Institute · Updated on 2025-12-08
1158
Participants Needed
1
Research Sites
317 weeks
Total Duration
On this page
Sponsors
M
Montreal Heart Institute
Lead Sponsor
U
Université de Montréal
Collaborating Sponsor
AI-Summary
What this Trial Is About
The NEPTUNE triple-blind, active-placebo, adaptive, pragmatic, randomized trial aims to evaluate the effectiveness of a new intra-venous hydration strategy guided by left ventricular end-diastolic pressure (LVEDP), amount of contrast used, and baseline renal function, to prevent contrast-induced acute kidney injury (CI-AKI) and patient-oriented clinical endpoints in all-comer patients undergoing coronary angiogram and/or percutaneous coronary intervention (PCI).
CONDITIONS
Official Title
ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Planned coronary angiogram and/or percutaneous coronary intervention (PCI)
- Willingness to participate and attend study visits
- Expected life expectancy of at least 6 months
You will not qualify if you...
- Cardiogenic or non-cardiogenic shock at the time of the procedure
- Emergent procedures such as STEMI
- Received iodine-based contrast media within 2 days
- Presence of intra-aortic balloon pump (IABP)
- Cardiac arrest within 24 hours
- Pre-procedural acute kidney injury within 7 days
- Receiving renal replacement therapy
- Severe aortic or mitral valve disease
- Left ventricular ejection fraction below 30%
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Montreal Heart Institute
Montreal, Quebec, Canada, H1T1C8
Actively Recruiting
Research Team
G
Guillaume Marquis-Gravel, MD, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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