Actively Recruiting

Phase 3
Age: 18Years +
All Genders
Healthy Volunteers
NCT05732272

Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

Led by University of Kansas Medical Center · Updated on 2026-02-23

500

Participants Needed

1

Research Sites

217 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study will evaluate the efficacy of extended bupropion(6 months) versus standard bupropion treatment (7 weeks) among African American daily smokers.

CONDITIONS

Official Title

Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • African American
  • Age greater than 18 years
  • Interested in quitting smoking
  • Smoked more than 1 cigarette per day for over 1 year
  • Smoked on more than 25 days in the past month
  • Willing to take 6 months of study medication and complete all visits
  • Have a home address and functioning telephone number
Not Eligible

You will not qualify if you...

  • Use of psychoactive medications
  • History of alcohol or substance abuse within the past year
  • Binge drinking (more than 5 drinks on one occasion) more than 2 times in the past month
  • History of seizures or head trauma
  • History of bulimia or anorexia nervosa
  • Pregnant or contemplating pregnancy; breastfeeding
  • Myocardial infarction in the past 2 months
  • Use of opiates, cocaine, or stimulants
  • Unstable diabetes
  • Taking drugs highly metabolized by liver enzyme CYP2D6 (e.g., metoprolol, tamoxifen)
  • Use of stop smoking medications (bupropion, varenicline, nicotine replacement, fluoxetine, clonidine, buspirone, or doxepin) in the past 30 days
  • Planning to move from the Kansas City area in the next year
  • Another smoker in household enrolled in the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Kansas Medical Center

Kansas City, Missouri, United States, 64130

Actively Recruiting

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Research Team

T

Tricia Snow, MPH

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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