Actively Recruiting

Phase Not Applicable
Age: 21Years +
All Genders
NCT03857529

Improving Stroke Motor Control With Non-invasive Brain Stimulation and Functional Electrical Stimulation

Led by MetroHealth Medical Center · Updated on 2025-09-29

15

Participants Needed

1

Research Sites

469 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This pilot study for stroke patients with chronic upper limb hemiplegia will examine the effects of non-invasive brain stimulation and neuromuscular electrical stimulation on hand motor control and corticospinal excitability. Specifically, this study will investigate the effects of timing and delivery of tDCS in conjunction with contralaterally controlled functional electrical stimulation.

CONDITIONS

Official Title

Improving Stroke Motor Control With Non-invasive Brain Stimulation and Functional Electrical Stimulation

Who Can Participate

Age: 21Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 21 years or older
  • At least 6 months since first clinical hemorrhagic or nonhemorrhagic stroke
  • Able to follow 3-stage commands and remember 2 of 3 items after 30 minutes
  • Full voluntary elbow extension/flexion and hand opening/closing of unaffected limb
  • Adequate active shoulder and elbow movement to position paretic hand for tabletop tasks
  • Able to sit unassisted in an armless straight-back chair during screening
  • Medically stable
  • At least 10 degrees finger extension
  • Unilateral upper limb hemiparesis with finger extensor strength of grade 4 or less
  • Score between 1 and 11 out of 14 on the hand section of the upper extremity Fugl-Meyer Assessment
  • Skin intact on hemiparetic arm, hand, and scalp
  • Surface neuromuscular electrical stimulation produces functional hand opening without pain
  • No significant visual or hearing impairment
Not Eligible

You will not qualify if you...

  • Other neurological conditions affecting the hemiparetic upper limb besides prior stroke
  • Uncontrolled seizure disorder
  • Use of seizure-lowering medications as determined by study physician
  • Cardiac pacemaker, implanted electronic device, or stent
  • Pregnant
  • Intramuscular botox injections in upper extremity muscles within last 3 months
  • Insensate arm, forearm, or hand
  • Severe cognitive or communication impairment
  • Uncompensated hemi-neglect
  • Severe shoulder or hand pain preventing hand positioning
  • Metal implant in the head

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

MetroHealth Medical Center

Cleveland, Ohio, United States, 44109

Actively Recruiting

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Research Team

D

David A Cunningham, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

TREATMENT

Number of Arms

5

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