Actively Recruiting
Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)
Led by Murdoch Childrens Research Institute · Updated on 2026-04-20
40
Participants Needed
4
Research Sites
124 weeks
Total Duration
On this page
Sponsors
M
Murdoch Childrens Research Institute
Lead Sponsor
R
Royal Children's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
A challenge to intermittent vancomycin dosing in young infants is the avoidable delay caused by the need to wait until steady state (i.e. when the drug concentrations are in equilibrium) to measure a vancomycin concentration, as this generally occurs 24 to 48 hours after starting treatment. If the target concentration is not achieved, the dose needs to be adjusted, resulting in further delays in an infant achieving the concentration required to treat their infection. The purpose of this study is to assess the use of early therapeutic drug monitoring (first-dose trough) and, if needed, early dose adjustment, in achieving target vancomycin concentrations at steady state. A dose adjustment calculator (available through a web application) will be used to determine the need for dose adjustment (based on predicted steady state concentration) and recommend an adjusted dose if required.
CONDITIONS
Official Title
Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants aged 0 to 90 days old
- Suspected infection requiring treatment with vancomycin for 48 hours or more as determined by the clinical team
You will not qualify if you...
- Infants with a corrected gestational age of less than 25 weeks
- Infants weighing less than 500 grams
- Known allergy to any glycopeptide antibiotic
- Vancomycin administered within the previous 72 hours
- Infants receiving any form of extracorporeal life support
- Renal impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Royal Children's Hospital Melbourne
Melbourne, Victoria, Australia, 3052
Actively Recruiting
2
Monash Newborn
Melbourne, Australia
Not Yet Recruiting
3
Royal Hospital for Women
Sydney, Australia
Not Yet Recruiting
4
The Children's Hospital at Westmead
Sydney, Australia
Actively Recruiting
Research Team
A
Amanda Wilkins, MBBS
CONTACT
A
Amanda Gwee, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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