Actively Recruiting
Improving Therapeutic Ratio With Hypo Fractionated Stereotactic Radiotherapy for Brain Metastases
Led by Haaglanden Medical Centre · Updated on 2024-03-12
130
Participants Needed
1
Research Sites
241 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Randomized phase II trial. The study aims to investigate a different and potentially safer radio therapeutic treatment method for brain metastases. The current standard of stereotactic radiotherapy (SRT) in one or three fractions is compared to fractionated stereotactic radiotherapy (fSRT) in five fractions.
CONDITIONS
Official Title
Improving Therapeutic Ratio With Hypo Fractionated Stereotactic Radiotherapy for Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3e= 18 years
- At least one brain metastasis of large cell cancer suitable for SRT
- Karnofsky Performance Status �3e= 70
- Ability to provide written informed consent
- New brain metastases during follow-up after surgery allowed (when outside of resection cavity area)
- New brain metastases during follow-up after previous SRT allowed (when outside of previous irradiation field)
You will not qualify if you...
- Contra-indication for MRI scan
- Primary tumor of small cell lung cancer, germinoma or lymphoma
- Prior whole brain radiotherapy or SRT on the current target brain metastases (in field re-irradiation)
- Presence of leptomeningeal metastases
- Previous inclusion in the SAFESTEREO study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Haaglanden Medisch Centrum
Leidschendam, South Holland, Netherlands, 2262 BA
Actively Recruiting
Research Team
J
Jaap D Zindler, MD, PhD
CONTACT
M
Mirjam Mast, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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