Actively Recruiting
IMRT Alone for Stage IB Nasopharyngeal Carcinoma Without High-Risk Features
Led by Qiaojuan Guo · Updated on 2026-01-29
169
Participants Needed
1
Research Sites
259 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study aims to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) alone in patients with stage IB nasopharyngeal carcinoma (NPC) without high-risk features. The primary objective is to determine the therapeutic effectiveness of this approach
CONDITIONS
Official Title
IMRT Alone for Stage IB Nasopharyngeal Carcinoma Without High-Risk Features
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histopathologically confirmed, newly diagnosed nasopharyngeal carcinoma
- Age 18-70 years
- Stage IB disease (T1-2N1M0) per the 9th edition AJCC/UICC staging system
- Upper-neck nodal metastasis only with inferior border of every positive node at or above the inferior border of the hyoid bone
- ECOG performance status 0-2
- Adequate bone-marrow function
You will not qualify if you...
- Age above 70 years or below 18 years
- Matted lymph nodes: two or more contiguous nodes forming a confluent mass
- Largest metastatic lymph-node 3 cm or larger in longest dimension
- Lower-neck nodal metastasis with any positive node below the inferior border of the hyoid bone
- Prior malignancy except adequately treated basal-cell or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix
- Pregnancy or lactation (serum pregnancy test required for women of child-bearing potential; effective contraception mandatory during treatment)
- Previous radiotherapy to the head-and-neck region
- Prior chemotherapy or surgery for the primary tumour or metastatic nodes (diagnostic procedures excluded)
- Any severe comorbidity that would increase risk or affect protocol adherence, such as unstable cardiac disease, renal failure, chronic hepatitis, or uncontrolled psychiatric disorder
- History of severe hypersensitivity reactions
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fujian Cancer Hospital
Fuzhou, Fujian, China, 350000
Actively Recruiting
Research Team
Q
Qiaojuan Guo, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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