Actively Recruiting
IMRT and Primary Transoral Surgery in the Treatment of Squamous Cell Carcinomas
Led by Gustave Roussy, Cancer Campus, Grand Paris · Updated on 2025-05-08
150
Participants Needed
16
Research Sites
675 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Compare patients' feelings in terms of swallowing ability assessed by the overall score of MD Anderson Dysphagia Inventory (MDADI) 2 years after starting treatment between patients who have been treated with IMRT and those who were treated by transoral surgery for a squamous cell carcinoma of the early stage oropharynx.
CONDITIONS
Official Title
IMRT and Primary Transoral Surgery in the Treatment of Squamous Cell Carcinomas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- ECOG performance status between 0 and 2
- Histologically confirmed squamous cell carcinoma
- Tumor located in the tonsil compartment or base of the tongue in the oropharynx
- Available p16 or HPV status
- Tumor stage T1 or T2 according to AJCC7th
- Lymph node stage N0 or N1 according to AJCC7th
- Tumor and patient suitable for radiotherapy or transoral surgery
- Patient has given informed consent and is willing to cooperate with follow-up and study visits
You will not qualify if you...
- Severe medical condition or contraindications to radiotherapy or surgery
- Unresectable primary tumor or lymphadenopathy
- Presence of metastatic disease
- History of head and neck squamous cell carcinoma within the past 5 years
- Previous radiation therapy to the head and neck
- Unable to undergo or complete radiation therapy follow-up
- History of cancer within 5 years except non-melanoma skin cancers
- Unable to complete study questionnaires
- Pregnant or breastfeeding women
- Patients under legal guardianship, deprived of liberty, or unable to consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
Gustave Roussy
Villejuif, Val De Marne, France, 94800
Actively Recruiting
2
Centre Hospitalier InterCommunal
Créteil, France, 94000
Actively Recruiting
3
Centre Oscar Lambret
Lille, France, 59000
Actively Recruiting
4
Hôpital la Croix Rousse
Lyon, France, 69004
Actively Recruiting
5
Centre Léon Bérard
Lyon, France, 69008
Actively Recruiting
6
CHU Conception
Marseille, France, 13005
Actively Recruiting
7
CHU Montpellier
Montpellier, France, 34090
Actively Recruiting
8
CHU Nantes - Hôtel Dieu
Nantes, France, 44000
Actively Recruiting
9
Institut Universitaire de la face et du cou
Nice, France, 06100
Actively Recruiting
10
Hôpital Européen Georges Pompidou
Paris, France, 75015
Actively Recruiting
11
CHU Reims
Reims, France, 51100
Actively Recruiting
12
Hôpital Charles Nicolle
Rouen, France, 76000
Actively Recruiting
13
CHU Hôpital de Hautepierre
Strasbourg, France, 67200
Actively Recruiting
14
Institut Claudius Regaud
Toulouse, France, 31100
Actively Recruiting
15
CHU Tours
Tours, France, 37000
Actively Recruiting
16
CHRU Nancy - Hôpital de Brabois
Vandœuvre-lès-Nancy, France, 54500
Actively Recruiting
Research Team
P
Philippe Gorphe, MD
CONTACT
T
Thibaud Motreff
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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