Actively Recruiting

Phase Not Applicable
Age: 60Years - 80Years
All Genders
NCT07349706

IMST for Dementia Risk Reduction

Led by Florida State University · Updated on 2026-03-27

30

Participants Needed

1

Research Sites

54 weeks

Total Duration

On this page

Sponsors

F

Florida State University

Lead Sponsor

N

National Institutes of Health (NIH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine secondary effects of IMST on mood, sleep quality, systemic inflammation, and physical/motor function. Finally, investigators will assess participant adherence and acceptability ratings of using an 8-week home-based IMST protocol in a diverse older adult sample.

CONDITIONS

Official Title

IMST for Dementia Risk Reduction

Who Can Participate

Age: 60Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Ages 60 to 80 years
  • Converted telephone MoCA total score of 18 or higher
  • Presence of at least one dementia risk factor such as mild cognitive impairment or subjective cognitive decline, hypertension (systolic blood pressure over 130 mmHg or on medication), sedentary lifestyle (less than 150 minutes per week), family history of dementia or self-reported APOE b54 carrier, or mild sleep-disordered breathing
  • Able to complete or need only minimal help with inspiratory muscle strength training
  • Willing to follow the IMST protocol for about 5 to 10 minutes daily over 8 weeks
  • Optional: inspiratory muscle weakness as defined by maximal inspiratory pressure below 80 cmH2O for men or below 70 cmH2O for women will be assessed
Not Eligible

You will not qualify if you...

  • Converted telephone MoCA score below 18 or diagnosis of neurodegenerative illness except mild cognitive impairment
  • Current major psychiatric disorders including psychosis, bipolar disorder, or severe major depression (PHQ-9 score over 20)
  • Unstable cardiovascular or lung disease
  • Recent respiratory therapy or major changes in medications
  • Severe untreated or unstable obstructive sleep apnea
  • Recent start (within past month) of CPAP or BiPAP treatment or recent use of inspiratory muscle training
  • Lung or eardrum injuries
  • Non-English speaking
  • Presence of pacemaker or other medical implants with magnets or electronics, excluding for body composition analyses

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Florida State University

Tallahassee, Florida, United States, 32301

Actively Recruiting

Loading map...

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here