InAdvance Study Collecting Samples and Information to Detect and Prevent Cancer in People at Increased Risk or With Early Signs

What this Trial Is About

Researchers are conducting a study to gather and store samples and information from individuals who might be at higher risk of developing cancer or have early-stage cancer or precursor conditions, as well as their family members. The study aims to identify exposures and clinical, molecular, and pathological changes that help predict early cancer development, progression, and malignant transformation. The ultimate goal is to find new markers for early detection and risk assessment that could guide future treatments to prevent cancer progression. Participants will provide tissue samples during routine visits, including blood, saliva or mouthwash, urine, stool, biopsy or surgical tissue such as bone marrow, bodily fluids, or other tissues. Participants will also complete a survey about their demographics, medical history, and family history. Family members of participants may also provide blood or saliva samples through various collection methods, including at consent, by mail, or at a separate appointment. During the study, participants will have clinical information and specimens collected for research analysis. Researchers will monitor exposures and changes over five years to understand cancer risk and progression. About 5,000 people are expected to participate. The study includes data collection from questionnaires, tissue sampling, and molecular analysis to identify markers that predict cancer development and progression. Participants health and safety are monitored throughout the study period, which can last several years.

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer