Study of Cerebral Vasospasm in Adults with Moderate to Severe Traumatic Brain Injury and Subarachnoid Hemorrhage at Martinique University Hospital

What this Trial Is About

Researchers are studying moderate to severe traumatic brain injury TBI complicated by subarachnoid hemorrhage SAH, focusing on the occurrence and evolution of cerebral vasospasm CV with clinical impact. CV is well described in aneurysmal SAH but less understood in traumatic cases, despite its potential impact on patient outcomes. This study aims to better define the incidence and characteristics of CV in this population at Martinique University Hospital using advanced imaging techniques. The study involves hospitalized patients with moderate or severe TBI Glasgow Score 13 and traumatic SAH seen on initial brain CT scan. Patients will receive routine clinical monitoring including daily transcranial Doppler TCD and biological assessments. If neurological deterioration or increased intracranial pressure occurs between days 3 and 12, a cerebral CT scan with an additional brain perfusion sequence will be performed to diagnose CV. Treatment to improve cerebral perfusion and manage intracranial pressure will continue as per standard care. Participants will be closely monitored during hospitalization with clinical exams, imaging, and neurological assessments. The study will estimate the incidence of CV with clinical impact over 42 months and describe its characteristics and risk factors. Neurological outcomes will be compared at 30 days and 6 months, with quality of life also assessed. Informed consent will be obtained from patients or their representatives, and data collection will include multiple follow-up points to understand CVs effect on recovery and prognosis.

Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital