Actively Recruiting
Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome
Led by Bicetre Hospital · Updated on 2026-03-05
500
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
Sponsors
B
Bicetre Hospital
Lead Sponsor
T
Tenon Hospital, Paris
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection. It is treated by artificial ventilation with the application of positive pressure. Pulmonary injury, coupled with artificial ventilation, can lead to right heart failure which hinders the ejection of blood to the pulmonary circulation. Modern mechanical ventilation modalities have reduced the frequency ("incidence") of this right heart failure in acute respiratory distress syndrome. A large-scale study has shown this a few years ago. However, the evolution of right heart failure during artificial ventilation, and the consequences it has on the patient's cardiovascular status are poorly determined. This study is conducted to improve knowledge in this area. In adult patients hospitalized in intensive care presenting acute respiratory distress syndrome, the investigators will collect the data recorded on cardiac ultrasound, doses of cardiovascular drugs as well as variables reflecting hemodynamic status and cell oxygenation. Data will be collected during the course of ARDS and mechanical ventilation, as well as after weaning from artificial ventilation.
CONDITIONS
Official Title
Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65;18 years old
- Hospitalized in intensive care and undergoing mechanical ventilation
- Diagnosed with acute respiratory distress syndrome (ARDS) according to the Berlin definition
- Have at least one echocardiography performed during the first 24 hours, between day 2 and 3, between day 5 and 7, and within 48 hours after extubation
You will not qualify if you...
- Pregnancy
- Poor ultrasound image quality preventing reliable measurement of right and left heart ventricles
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chu de Bicêtre, AP-HP
Le Kremlin-Bicêtre, France, 94270
Actively Recruiting
Research Team
X
Xavier Monnet, MD, PhD
CONTACT
C
Christopher Lai, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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