Actively Recruiting

Age: 18Years +
All Genders
NCT07450846

Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome

Led by Bicetre Hospital · Updated on 2026-03-05

500

Participants Needed

1

Research Sites

262 weeks

Total Duration

On this page

Sponsors

B

Bicetre Hospital

Lead Sponsor

T

Tenon Hospital, Paris

Collaborating Sponsor

AI-Summary

What this Trial Is About

Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection. It is treated by artificial ventilation with the application of positive pressure. Pulmonary injury, coupled with artificial ventilation, can lead to right heart failure which hinders the ejection of blood to the pulmonary circulation. Modern mechanical ventilation modalities have reduced the frequency ("incidence") of this right heart failure in acute respiratory distress syndrome. A large-scale study has shown this a few years ago. However, the evolution of right heart failure during artificial ventilation, and the consequences it has on the patient's cardiovascular status are poorly determined. This study is conducted to improve knowledge in this area. In adult patients hospitalized in intensive care presenting acute respiratory distress syndrome, the investigators will collect the data recorded on cardiac ultrasound, doses of cardiovascular drugs as well as variables reflecting hemodynamic status and cell oxygenation. Data will be collected during the course of ARDS and mechanical ventilation, as well as after weaning from artificial ventilation.

CONDITIONS

Official Title

Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 65;18 years old
  • Hospitalized in intensive care and undergoing mechanical ventilation
  • Diagnosed with acute respiratory distress syndrome (ARDS) according to the Berlin definition
  • Have at least one echocardiography performed during the first 24 hours, between day 2 and 3, between day 5 and 7, and within 48 hours after extubation
Not Eligible

You will not qualify if you...

  • Pregnancy
  • Poor ultrasound image quality preventing reliable measurement of right and left heart ventricles

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Chu de Bicêtre, AP-HP

Le Kremlin-Bicêtre, France, 94270

Actively Recruiting

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Research Team

X

Xavier Monnet, MD, PhD

CONTACT

C

Christopher Lai, MD, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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