Actively Recruiting
Predicting Moderate Thoracic Aortic Aneurysm Evolution: a Longitudinal Study of Systemic Factors in Patients Free of Connective Tissue Disease
Led by University Hospital, Lille · Updated on 2026-05-15
320
Participants Needed
1
Research Sites
23 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Lille
Lead Sponsor
S
Santelys Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying thoracic aortic aneurysm, a condition that can be silent but carries a risk of serious complications or death over time. This observational study aims to understand the rate of major complications in patients with small to moderate thoracic aneurysms. It also seeks to identify systemic factors, such as blood pressure and sleep disorders, that might influence the aneurysm's progression. The study follows patients with documented aortic root aneurysms larger than 40 mm but excludes those with larger or rapidly progressing aneurysms or certain medical conditions. Participants will be observed over a five-year period to monitor the occurrence of major aortic events. Blood pressure control and sleep disorders will also be assessed during the first two years. Participants will be involved in regular clinical and imaging follow-ups over five years. Researchers will collect data on major cardiovascular and aortic events, blood pressure control through ambulatory measurements, and sleep disorder indicators like the Apnea Hypopnea Index and Oxygen Desaturation Index. This long-term observation helps understand aneurysm evolution and related risks in this patient group.
CONDITIONS
Brief Title
Incidence of Major Complication in Case of Thoracic Aortic Aneurysm
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documentation of an aortic root aneurysm > 40 mm
- Agreement to participate in a longitudinal study and available for a 5-year follow-up
- Age between 45 and 80 years
You will not qualify if you...
- Presence of comorbidities or pathology with a prognosis of less than 1 year
- Personal or family history of genetically documented elastic tissue disease or meeting clinical criteria suggestive of Marfan disease
- High-grade mitral or aortic valve disease, even if asymptomatic
- Unbalanced hypertension with blood pressure ≥ 180/110 mmHg
- Any aneurysm (thoracic or abdominal) ≥ 50 mm
- Aneurysm with documented progression of more than 5 mm over one year
- History of aortic surgery, endovascular intervention, or type B aortic dissection treated medically
- Renal insufficiency on dialysis or with GFR < 30 ml/min (CKD-EPI)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 5 years
Participants are observed over several years to monitor the occurrence of major aortic and cardiovascular events, as well as control of blood pressure and presence of sleep disorders.
Periodic visits over 5 years for assessments and monitoring
Trial Site Locations
Total: 1 location
1
CHU Lille
Lille, Please Choose..., France, 59037
Actively Recruiting
Research Team
P
Pascal DELSART, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here