Actively Recruiting
Incident Chronic Obstructive Pulmonary Disease Cohort Study (ICONIC) Evaluating Systematic Screening and Patient Evolution in COPD Among Smokers
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-01-09
300
Participants Needed
1
Research Sites
287 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic Obstructive Pulmonary Disease (COPD) related to smoking is a significant public health concern with high costs, and many patients remain undiagnosed. This research aims to better understand the progression of newly diagnosed COPD patients by screening smokers in general medicine and specialized respiratory departments. The study seeks to identify different disease evolutions based on initial patient characteristics and management, as current data on real-life patient outcomes after diagnosis is limited. Participants who are smokers will undergo a thorough evaluation including clinical investigations, imaging, blood tests, respiratory function tests, and assessments of muscle and skeletal function. The study plans to include 1500 smokers to identify 300 with COPD, ensuring equal representation of men and women with COPD (150 men and 150 women). Screening spirometry will be used to detect COPD among participants. During the study, participants will be closely monitored to track their health progression over one year, focusing on any adverse outcomes. Researchers will collect detailed medical data and perform comprehensive assessments to understand how COPD develops and responds to care. The study emphasizes long-term follow-up to improve understanding of COPD management and patient health goals.
CONDITIONS
Official Title
Incident Chronic Obstructive pulmoNary dIsease Cohort Study (ICONIC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 35 years
- Smoking history of more than 20 pack-years
- Current active smoker or quit less than 1 month ago
- Signed consent to participate in Phase I of the study
- For patients with incidental COPD: FEV1/FVC less than 70% of predicted value and/or less than the lower limit of normal
- Signed consent to participate in Phase II of the study
You will not qualify if you...
- Previously known COPD diagnosis
- Currently receiving treatment for cancer
- No affiliation with social security or social protection scheme
- Pregnant or breastfeeding women
- Patients deprived of liberty or under legal protection (such as guardianship or curatorship)
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Trial Site Locations
Total: 1 location
1
Hopital Henri MONDOR
Créteil, Île-de-France Region, France, 94000
Actively Recruiting
Research Team
L
Laurent BOYER, MD
L
Lila KACI
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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