Actively Recruiting

Phase Not Applicable
Age: 35Years +
All Genders
ID04252781

Incident Chronic Obstructive Pulmonary Disease Cohort Study (ICONIC) Evaluating Systematic Screening and Patient Evolution in COPD Among Smokers

Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-01-09

300

Participants Needed

1

Research Sites

287 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Chronic Obstructive Pulmonary Disease (COPD) related to smoking is a significant public health concern with high costs, and many patients remain undiagnosed. This research aims to better understand the progression of newly diagnosed COPD patients by screening smokers in general medicine and specialized respiratory departments. The study seeks to identify different disease evolutions based on initial patient characteristics and management, as current data on real-life patient outcomes after diagnosis is limited. Participants who are smokers will undergo a thorough evaluation including clinical investigations, imaging, blood tests, respiratory function tests, and assessments of muscle and skeletal function. The study plans to include 1500 smokers to identify 300 with COPD, ensuring equal representation of men and women with COPD (150 men and 150 women). Screening spirometry will be used to detect COPD among participants. During the study, participants will be closely monitored to track their health progression over one year, focusing on any adverse outcomes. Researchers will collect detailed medical data and perform comprehensive assessments to understand how COPD develops and responds to care. The study emphasizes long-term follow-up to improve understanding of COPD management and patient health goals.

CONDITIONS

Official Title

Incident Chronic Obstructive pulmoNary dIsease Cohort Study (ICONIC)

Who Can Participate

Age: 35Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age over 35 years
  • Smoking history of more than 20 pack-years
  • Current active smoker or quit less than 1 month ago
  • Signed consent to participate in Phase I of the study
  • For patients with incidental COPD: FEV1/FVC less than 70% of predicted value and/or less than the lower limit of normal
  • Signed consent to participate in Phase II of the study
Not Eligible

You will not qualify if you...

  • Previously known COPD diagnosis
  • Currently receiving treatment for cancer
  • No affiliation with social security or social protection scheme
  • Pregnant or breastfeeding women
  • Patients deprived of liberty or under legal protection (such as guardianship or curatorship)

AI-Screening

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Trial Site Locations

Total: 1 location

1

Hopital Henri MONDOR

Créteil, Île-de-France Region, France, 94000

Actively Recruiting

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Research Team

L

Laurent BOYER, MD

L

Lila KACI

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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