Comparing Vertebroplasty Plus Stereotactic Body Radiation Therapy to Radiation Therapy Alone for Pain Relief in Spine Metastases

What this Trial Is About

Researchers are studying patients with spine metastases to evaluate whether adding vertebroplasty before stereotactic body radiation therapy SBRT can provide better early pain relief compared to SBRT alone. The study aims to understand if this combined approach reduces fractures and post-treatment pain, as the benefit of vertebroplasty before radiotherapy is not well documented. The trial is led by the Centre hospitalier de lUniversit de Montral CHUM and involves patients suitable for SBRT treatment with specific spinal metastases and pain levels. Participants are randomly assigned to one of two groups. One group receives vertebroplasty followed by SBRT, while the other group receives only SBRT, which is the current standard care. Vertebroplasty involves injecting cement into the affected vertebrae under local anesthesia with imaging guidance, followed by a short recovery and same-day discharge. SBRT delivers precise radiotherapy in 1 to 5 treatment sessions targeting the metastatic spine lesions. During the study, participants will be monitored for changes in pain at 1 week, 1 month, 3 months, and 6 months after treatment. Researchers will also assess physical, psychological, and social function changes, symptoms related to bone metastasis, and ability to perform daily activities. Fracture rates will be tracked up to 24 months post-treatment. Participants will complete questionnaires on pain and quality of life, and their overall health and safety will be observed throughout the trial period.

Increased Early Pain Relief by Adding Vertebroplasty to SBRT