Actively Recruiting
Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment
Led by University Hospital, Geneva · Updated on 2025-12-23
120
Participants Needed
2
Research Sites
142 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Geneva
Lead Sponsor
C
Centre Hospitalier Universitaire Vaudois
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of the study is to investigate the clinical validity of tau-PET with \[18F\]RO948 vs. amyloid-PET in patients with Mild Cognitive Impairment (MCI) or mild dementia
CONDITIONS
Official Title
Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent to participate
- Between 50 and 85 years of age
- Diagnosed with Mild Cognitive Impairment (at least one pathological neuropsychological test but no functional impairment) or mild dementia (both cognitive and functional impairments)
- MRI scan available within 6 months before screening
- Prescription for diagnostic amyloid PET scan
- Willing and able to comply with study requirements as judged by investigator
You will not qualify if you...
- Presence of psychiatric disorders, extensive white matter lesions, or signs of vascular dementia
- Visual or hearing problems that would affect neuropsychological testing
- Participation in previous Alzheimer's disease clinical trials affecting amyloid or tau brain load
- Participation in other trials or studies incompatible with [18F]RO948 imaging
- Ferromagnetic implants or devices that make MRI scanning impossible
- Women of childbearing potential who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Geneva University Hospital
Geneva, Canton of Geneva, Switzerland, 1205
Actively Recruiting
2
Centre Medical Universitaire Vaudois
Lausanne, Canton of Vaud, Switzerland, 1211
Actively Recruiting
Research Team
V
Valentina Garibotto, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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