Actively Recruiting

Age: 18Years - 80Years
All Genders
ID07473375

Indicators Affecting Portal Vein Thrombosis Recanalization in Cirrhosis With Gastroesophageal Varices

Led by Shanghai Zhongshan Hospital · Updated on 2026-03-16

1500

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying portal vein thrombosis (PVT) in patients who have cirrhosis and gastroesophageal varices (GEV). This observational study, conducted at Zhongshan Hospital of Fudan University, aims to provide new insights into how PVT is diagnosed, monitored, and factors that affect its recanalization. The goal is to improve understanding for patients, families, and healthcare providers regarding this disease and its clinical management. The study observes patients who have been diagnosed with cirrhosis, confirmed gastroesophageal varices by endoscopy, and PVT confirmed by CTA imaging at admission. There are no interventions or treatments assigned by the study, as it is observational and retrospective-prospective in design. Researchers review patient records and imaging results over time to assess PVT recanalization and related outcomes. Participants are followed with abdominal imaging assessments starting from admission to track PVT recanalization at 1 year and 5 years, as well as occurrences of death or non-improved PVT. The main outcome measured is PVT recanalization within 1 year. Secondary outcomes include survival rates and PVT progression over 5 years. This long-term follow-up allows researchers to understand the disease course and factors influencing treatment outcomes.

CONDITIONS

Brief Title

Indicators Affecting PVT Recanalization

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with cirrhosis and confirmed gastroesophageal varices by endoscopy
  • Diagnosed with portal vein thrombosis by CT angiography (CTA) at admission
  • Age between 18 and 80 years
Not Eligible

You will not qualify if you...

  • Patients with hepatocellular carcinoma
  • Patients with extrahepatic malignancies
  • History of liver transplantation or transjugular intrahepatic portosystemic shunt (TIPS)
  • Lack of information regarding anticoagulation therapy
  • Presence of cavernous transformation of the portal vein (CTPV)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Diagnostic Evaluation

Duration - At admission

Participants undergo abdominal imaging assessments and confirmation of portal vein thrombosis and related conditions.

1 visit (in-person)

Long-term Monitoring

Duration - Up to 5 years

Participants are monitored for portal vein thrombosis recanalization, survival, and progression of their condition over several years.

Periodic follow-up visits for up to 5 years

Trial Site Locations

Total: 1 location

1

Shanghai, Shanghai Municipality, China, 200032

Actively Recruiting

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Research Team

S

Siyu Jiang, Dr.

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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