Actively Recruiting
Indicators Affecting Portal Vein Thrombosis Recanalization in Cirrhosis With Gastroesophageal Varices
Led by Shanghai Zhongshan Hospital · Updated on 2026-03-16
1500
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying portal vein thrombosis (PVT) in patients who have cirrhosis and gastroesophageal varices (GEV). This observational study, conducted at Zhongshan Hospital of Fudan University, aims to provide new insights into how PVT is diagnosed, monitored, and factors that affect its recanalization. The goal is to improve understanding for patients, families, and healthcare providers regarding this disease and its clinical management. The study observes patients who have been diagnosed with cirrhosis, confirmed gastroesophageal varices by endoscopy, and PVT confirmed by CTA imaging at admission. There are no interventions or treatments assigned by the study, as it is observational and retrospective-prospective in design. Researchers review patient records and imaging results over time to assess PVT recanalization and related outcomes. Participants are followed with abdominal imaging assessments starting from admission to track PVT recanalization at 1 year and 5 years, as well as occurrences of death or non-improved PVT. The main outcome measured is PVT recanalization within 1 year. Secondary outcomes include survival rates and PVT progression over 5 years. This long-term follow-up allows researchers to understand the disease course and factors influencing treatment outcomes.
CONDITIONS
Brief Title
Indicators Affecting PVT Recanalization
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with cirrhosis and confirmed gastroesophageal varices by endoscopy
- Diagnosed with portal vein thrombosis by CT angiography (CTA) at admission
- Age between 18 and 80 years
You will not qualify if you...
- Patients with hepatocellular carcinoma
- Patients with extrahepatic malignancies
- History of liver transplantation or transjugular intrahepatic portosystemic shunt (TIPS)
- Lack of information regarding anticoagulation therapy
- Presence of cavernous transformation of the portal vein (CTPV)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - At admission
Participants undergo abdominal imaging assessments and confirmation of portal vein thrombosis and related conditions.
1 visit (in-person)
Duration - Up to 5 years
Participants are monitored for portal vein thrombosis recanalization, survival, and progression of their condition over several years.
Periodic follow-up visits for up to 5 years
Trial Site Locations
Total: 1 location
1
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
Research Team
S
Siyu Jiang, Dr.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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