Actively Recruiting
Indicators and Evaluation of Efficacy of Yin-nourishing and Fire-reducing Chinese Medicine for Girls With Rapid Progression of Early Puberty
Led by Children's Hospital of Fudan University · Updated on 2025-02-11
80
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1\. Evaluate whether AMH and SHBG have differential expression before and after the diagnosis of rapid and slow progression types of early puberty and whether this difference has a predictive effect on the rapid progression type. 2. Assess the therapeutic effect of nourishing yin and purging fire traditional Chinese medicine on girls with rapid progression type of early puberty providing a standardized clinical basis for the formulation of diagnostic and treatment guidelines (or protocols) for the rapid progression type of early puberty using traditional Chinese medicine
CONDITIONS
Official Title
Indicators and Evaluation of Efficacy of Yin-nourishing and Fire-reducing Chinese Medicine for Girls With Rapid Progression of Early Puberty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Girls aged over 8 years and up to 9 years
- Breast bud Tanner stage II with breast bud diameter less than 3 cm
- Ultrasound showing unilateral ovarian volume between 1 and 3 ml and/or follicle diameter of 4 mm or more
- Bone age not exceeding actual age by more than 1 year
- LHRH stimulation test with LH/FSH ratio less than or equal to 0.6 and LH peak less than or equal to 5.0 IU/L
- Good compliance with study procedures
- Patients and parents willing to actively cooperate with the clinical trial
- Legal guardian has signed the informed consent form
You will not qualify if you...
- Disorders of gonadal development such as chromosomal abnormalities, hypospadias, or intersex conditions
- Use of treatments affecting gonadal function, including chemotherapy or radiotherapy
- Diabetes, thyroid dysfunction, obesity, lipid metabolism disorders, or other congenital diseases
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China, 201102
Actively Recruiting
Research Team
W
Wen Sun
CONTACT
T
Teng Fan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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