Actively Recruiting
Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity
Led by Australian and New Zealand Intensive Care Research Centre · Updated on 2025-07-25
60
Participants Needed
5
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The DIRECT trial is a prospective, multi-centre, two arm parallel feasibility pilot randomised controlled trial. The primary aim is to determine the feasibility of using repeat indirect calorimetry measurements to direct energy delivery in critically ill patients with obesity. The trial will recruit 60 mechanically ventilated patients from 4-6 ICUs in Australia and New Zealand.
CONDITIONS
Official Title
Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (≥ 18 years) patients
- Body mass index ≥30 kg/m2
- Between day 3 and 6 of index ICU admission
- Receiving invasive mechanical ventilation
- Receiving enteral or parenteral nutrition
You will not qualify if you...
- Receiving extracorporeal membrane oxygenation support
- Major burns (≥20% total body surface area)
- Unable to perform indirect calorimetry within 24 hours of randomisation
- Known pregnancy
- Death is imminent
- Treating clinician believes the study is not in the best interest of the patient
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 5 locations
1
Blacktown Hospital
Blacktown, New South Wales, Australia, 2148
Actively Recruiting
2
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
3
Ballarat Base Hospital, Grampians Health
Ballarat Central, Victoria, Australia, 3550
Actively Recruiting
4
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Actively Recruiting
5
Department of Critical Care Medicine, Auckland City Hospital
Auckland, New Zealand, 1023
Not Yet Recruiting
Research Team
O
Oana Tatucu
CONTACT
E
Emma Ridley
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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