Actively Recruiting
Led by West China Hospital · Updated on 2024-12-04
40
Participants Needed
1
Research Sites
30 weeks
Total Duration
Researchers are evaluating an individualized acute normovolemic hemodilution (ANH) technique to reduce the need for red blood cell transfusions during elective non-cardiac surgeries with expected major blood loss in adults aged 18 to 75 years. The study aims to address concerns about complications related to allogeneic blood transfusions and improve blood management during surgery by tailoring the ANH process to each patient using the West-China-Liu's Score. Participants in the trial will be randomly assigned to either receive individualized ANH based on the West-China-Liu's Score after anesthetic induction or to receive routine clinical care guided by standard transfusion guidelines. The individualized ANH involves collecting autologous blood while infusing fluids to maintain blood volume, with transfusions managed according to the patient's calculated tolerable hemoglobin level. This method aims to safely reduce red cell loss during surgery. During the study, researchers will monitor participants for the requirement of allogeneic blood transfusions up to 12 weeks post-surgery. Additional assessments include the proportion of patients receiving transfusions, in-hospital complications, duration of hospital and postoperative stays, and total hospital costs. Safety and outcomes will be evaluated through standard clinical monitoring throughout the hospital stay and follow-up period.
CONDITIONS
Individualized ANH for Non-cardiac Surgery
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - During surgery
Participants undergo individualized acute normovolemic hemodilution (ANH) based on the West-China Liu's Score after anesthetic induction during elective non-cardiac surgery. The decision for autologous or allogeneic red cell transfusion is made according to this score.
1 surgical procedure visit (in-person)
Duration - Up to 12 weeks
Participants are monitored for up to 12 weeks after surgery to assess transfusion requirements, complications, and recovery outcomes.
Regular post-operative visits according to clinical practice
Total: 1 location
1
West China Hospital of Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
R
Ren Liao, M.D.
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Chenxi Liao, Jinzhe Tan, Jingjing An...
https://pubmed.ncbi.nlm.nih.gov/39753262