Actively Recruiting
Individualized Exploration of Aerobic Exercise-assisted Treatment of Depression
Led by Peking University · Updated on 2025-07-02
80
Participants Needed
1
Research Sites
67 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this project is to quantify the relative effectiveness of aerobic exercise monitored by smart wristbands in assisting the treatment of depression and improving cognitive function. It aims to explore the mechanisms through which aerobic exercise exerts its effects using imaging genetics and other methods, and to identify suitable populations for exercise, ultimately providing personalized clinical exercise prescriptions. This study will intervene from a behavioral perspective and also seeks to motivate participants to change and improve their physical activity habits.
CONDITIONS
Official Title
Individualized Exploration of Aerobic Exercise-assisted Treatment of Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-45 years (including 18 and 45), no gender restriction
- Meets diagnostic criteria for depressive disorders according to DSM-V
- Outpatients or inpatients with HAMD-17 score 2 14
- Negative Mood Disorder Questionnaire screening to exclude bipolar disorder
- Clinical Global Impressions-Severity score 2 4
- Maintained on antidepressant treatment for at least 4 weeks or not using antidepressants
- Written informed consent obtained from the patient
You will not qualify if you...
- Diagnosed with other mental disorders such as schizophrenia, bipolar disorder, substance abuse, or eating disorders
- Intellectual disabilities or inability to cooperate or incomplete civil capacity during illness onset
- Neurological or organic brain diseases like stroke, brain tumors, Parkinson's disease, epilepsy, or severe brain injury
- Conditions with high exercise risk such as hypertension or heart disease
- Currently undergoing systematic psychological therapy
- Males with recovery heart rate over 131 and females over 140 in the 3-minute step test
- Physical restrictions preventing participation in exercise
- Physical Activity Readiness Questionnaire score 2
- Pregnant or contraindicated for MRI examination
- Severe suicidal tendencies or risk of harm to others
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking University Sixth Hostipal
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
Research Team
W
Weihua Yue, Doctor
CONTACT
G
Guorui Zhao
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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