Actively Recruiting
Exploration of the Efficacy of Individualized Transcranial Magnetic Stimulation in the Treatment of Parkinsonian Disorders
Led by Peking University First Hospital · Updated on 2026-05-06
50
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
Sponsors
P
Peking University First Hospital
Lead Sponsor
C
Changping Laboratory
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether individualized targeted repetitive transcranial magnetic stimulation (rTMS) can improve both motor and non-motor symptoms in patients with parkinsonian disorders, including Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy. The study aims to determine if this treatment alleviates symptoms and which clinical features respond best to the therapy. Participants will receive a 10-day rTMS treatment over two weeks, with sessions held once daily from Monday to Friday. The stimulation uses intermittent theta burst stimulation (iTBS) targeting specific brain areas with a figure-of-eight coil in the left hemisphere. Each day involves multiple stimulation trains totaling 14,400 pulses. Before treatment, participants undergo screening with clinical assessments, MRI, and EEG. Follow-up assessments occur immediately after treatment and again 10 weeks later. During the study, participants will have clinical tests, MRI scans, and EEG recordings to evaluate changes in motor function, mobility, and non-motor symptoms. Researchers will measure outcomes such as motor symptom changes using the MDS-UPDRS Part III scale, mobility with the 5-meter Timed Up and Go test, and non-motor symptoms via a questionnaire. Safety and treatment effects will be monitored throughout the study period lasting approximately 12 weeks from screening to final follow-up.
CONDITIONS
Brief Title
Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically established or probable diagnosis of Parkinson's Disease, Multiple System Atrophy, or Progressive Supranuclear Palsy according to MDS criteria
- Age between 30 and 80 years, inclusive
- PD patients with Modified Hoehn and Yahr stage 2-4
- MSA patients with UMSARS Part IV stage 1-4
- PSP patients with Modified Rankin Scale grade 2-4
- Ability to understand and comply with study requirements and provide written informed consent
You will not qualify if you...
- Presence of intracranial metallic implants or foreign bodies such as cochlear implants or pacemakers
- Known allergy to EEG conductive paste or contraindications to EEG
- History of claustrophobia, incompatible implants, or extensive tattoos preventing MRI
- Currently receiving TMS or other physical therapies like tDCS
- Unstable systemic diseases needing urgent treatment
- Personal or family history of epilepsy
- History of moderate-to-severe psychiatric disorders
- Chronic insomnia or regular use of sedative-hypnotics
- Current use of medications that significantly affect central nervous system excitability
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 10 consecutive working days
Participants receive individualized transcranial magnetic stimulation (iTBS) sessions targeting the left hemisphere's somato-cognitive action network sites over ten consecutive working days.
Daily visits for 10 days with multiple stimulation sessions per day
Duration - 10 weeks
Participants are monitored for changes in motor and non-motor symptoms up to 10 weeks after treatment.
1 to 2 visits depending on assessments
Trial Site Locations
Total: 1 location
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
Research Team
L
Luhua Wei, M.D.
K
Kai Li, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here