Actively Recruiting
Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders
Led by Peking University First Hospital · Updated on 2026-05-06
50
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
P
Peking University First Hospital
Lead Sponsor
C
Changping Laboratory
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial aims to evaluate whether individualized targeted repetitive transcranial magnetic stimulation (rTMS) can improve motor and non-motor symptoms in patients with parkinsonian disorders. The main question it aims to answer is: * Does individualized targeted rTMS alleviate symptoms of parkinsonian disorders? * Which clinical manifestations of parkinsonian syndromes are responsive to individualized targeted rTMS, and to what degree? Procedures: * Preparation (Screening) Participants will undergo clinical assessments, MRI, and EEG before the treatment. * Treatment (2 Weeks) Participants will receive a 10-day TMS treatment (once daily, Monday-Friday). Each treatment day takes approximately 3-4 hours. Participants need to keep stable medications and rehabilitation routines during this time. * Follow-up (10 Weeks) Participants will undergo follow-up assessments at the end of treatment and 10 weeks after treatment. Assessments include clinical scales, MRI, and EEG.
CONDITIONS
Official Title
Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically established or probable Parkinson's Disease, Multiple System Atrophy, or Progressive Supranuclear Palsy based on specified MDS diagnostic criteria
- Aged 30 to 80 years, no gender restrictions
- Disease severity: PD with Hoehn and Yahr stage 2-4; MSA with UMSARS Part IV stage 1-4; PSP with Modified Rankin Scale grade 2-4
- Ability to understand, comply with study requirements, and provide written informed consent
You will not qualify if you...
- Presence of intracranial metallic implants or foreign bodies such as cochlear implants or pacemakers
- Allergies to EEG conductive paste or other EEG contraindications; claustrophobia or incompatible implants for MRI; extensive tattoos
- Currently receiving transcranial magnetic stimulation or other therapeutic physical modalities like transcranial direct current stimulation
- Unstable systemic diseases needing urgent treatment
- Personal or family history of epilepsy; moderate-to-severe psychiatric or psychological disorders; chronic insomnia or regular use of sedative-hypnotics
- Use of medications that significantly alter central nervous system excitability
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
Research Team
L
Luhua Wei, M.D.
CONTACT
K
Kai Li, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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