Actively Recruiting
Individualized Tumor-Informed CtDNA Analysis for Monitoring Postoperative Recurrence in ESCC (NEOCRTEC2401)
Led by Sun Yat-Sen University Cancer Center · Updated on 2024-08-29
50
Participants Needed
1
Research Sites
196 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study or is to explore the correlation between dynamic changes in postoperative circulating tumor DNA (ctDNA) and recurrence risk using a novel, tumor-informed ctDNA detection technique, thus laying the foundation for further promoting ctDNA detection to guide postoperative adjuvant therapy decisions. This study focuses on patients with esophageal squamous cell carcinoma who did not achieve pCR following neoadjuvant therapy combined with surgical resection. The main question it aims to answer is: Is there a correlation between postoperative ctDNA changes and tumor recurrence? Participants will be asked to undergo postoperative ctDNA detection.
CONDITIONS
Official Title
Individualized Tumor-Informed CtDNA Analysis for Monitoring Postoperative Recurrence in ESCC (NEOCRTEC2401)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Operable locally advanced esophageal squamous cell carcinoma
- Received neoadjuvant chemoradiotherapy with or without immunotherapy
- Did not achieve pathological complete response after R0 surgical resection
- Able to tolerate postoperative adjuvant immunotherapy
- Sufficient baseline tumor tissue and blood samples available for next-generation sequencing testing
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1
- Consent to and capability of complying with study visits, treatment plans, tests, and procedures
- Expected postoperative survival time of 6 months or longer
You will not qualify if you...
- Presence of other malignant tumors at the same time
- Lack of detailed histopathological report for lesion diagnosis
- Severe or uncontrolled medical conditions that could affect participation or study results
- Social or psychological issues making participation unsuitable
- Unable to undergo long-term regular postoperative follow-up at the current medical center
- Unwilling or unable to follow the study protocol
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
H
Hong Yang, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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