Actively Recruiting
Individualized Versus Conventional Perioperative Blood Pressure Management
Led by Seoul National University Hospital · Updated on 2025-05-28
1896
Participants Needed
5
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study objective: To compare the effect of different perioperative blood pressure management strategies on major postoperative adverse outcomes / Study design: a multicenter, randomized controlled trial / Participants: 1896 patients undergoing major non-cardiac surgery / Methods: Patients are randomized into two groups, the individualized strategy (maintaining perioperative mean arterial pressure and systolic blood pressure more than -20% of their baseline values) or the conventional strategy (maintaining perioperative mean arterial pressure ≥65 mmHg and systolic blood pressure ≥90 mmHg in all patients). Then, the frequency of major postoperative adverse outcomes occurring within 7 postoperative days or before discharge (whichever occurs first). / Primary outcome: a composite of all-cause death, stroke, myocardial infarction, new or worsening congestive heart failure, unplanned coronary revascularization, and acute kidney injury, occuring within 7 postoperative days or before discharge (whichever occurs first).
CONDITIONS
Official Title
Individualized Versus Conventional Perioperative Blood Pressure Management
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 65 or older
- Patients aged 45 or older with a history of coronary artery disease, peripheral vascular disease, transient ischemic attack/stroke, or congestive heart failure
- Patients undergoing non-cardiac surgery under general anesthesia expected to last at least 2 hours
You will not qualify if you...
- Emergency surgery
- Organ transplantation surgery
- Brain or carotid artery surgery
- American Society of Anesthesiologists physical status 5 or 6
- Pregnancy
- Uncontrolled preoperative hypertension (systolic blood pressure 180 mmHg or higher, or diastolic blood pressure 110 mmHg or higher)
- Estimated glomerular filtration rate less than 30 ml/min/1.73m2
- Receiving renal replacement therapy
- Acute decompensated heart failure
- Sepsis
- Shock
- Use of inotropes or vasopressor infusions such as dopamine, norepinephrine, or vasopressin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Seoul National University Bundang Hospital
Seongnam, South Korea
Actively Recruiting
2
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
3
Korea University Guro Hospital
Seoul, South Korea
Actively Recruiting
4
Samsung Medical Center
Seoul, South Korea
Actively Recruiting
5
Ajou University Hospital
Suwon, South Korea
Actively Recruiting
Research Team
K
Karam Nam, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here