Using Indocyanine Green Fluorescence to Check Blood Flow in the Pancreas After Pancreaticoduodenectomy Surgery

What this Trial Is About

Researchers are evaluating the blood flow in the pancreatic remnant after pancreaticoduodenectomy using indocyanine green fluorescence. This is to see if this method can help estimate the risk of developing a postoperative pancreatic fistula, a serious complication that occurs in about 25% of these surgeries. The study is prospective and experimental, focusing on patients undergoing open pancreaticoduodenectomy from May 2024 to December 2026. During surgery, all patients will receive an intravenous application of indocyanine green fluorescence product, Verdye, to assess the blood supply of the pancreatic remnant with a fluorescence detector. Patients will be categorized into groups based on whether their pancreatic remnant shows hazardous or non-hazardous vascular supply. The study will compare the incidence of pancreatic fistula and other postoperative outcomes between these groups. Participants will be monitored from admission until discharge, with data collected on complications, mortality, length of hospital and intensive care stays, and development of pancreatic fistula. The primary measurement is the evaluation of blood flow during the operation using indocyanine green fluorescence within 5 to 10 minutes. Secondary outcomes include correlating perfusion results with fistula development over approximately two weeks post-surgery. The overall goal is to improve prediction of fistula risk and potentially guide surgical decisions.

Indocyanine Green Fluorescence in Evaluation of Pancreatic Remnant Perfusion.