Actively Recruiting
Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2
Led by Glostrup University Hospital, Copenhagen · Updated on 2025-08-08
32
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
Sponsors
G
Glostrup University Hospital, Copenhagen
Lead Sponsor
U
University of Copenhagen
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this trial is to investigate the biological effects of oral supplementation with indole-3-propionic acid (IPA) taken twice daily in healthy adults. The main scientific questions are: * Does supplementation with IPA increase the abundance of regulatory T cells in the blood? Regulatory T cells are believed to play an important role in preventing autoimmune diseases. * Does supplementation with IPA increase the concentration of brain-derived neurotrophic factor (BDNF) in the blood? BDNF is believed to play an important role in maintaining brain health. * Does supplementation with IPA affect blood analyses commonly performed to assess the risk of metabolic disorders like type 2 diabetes and cardiovascular diseases? Participants will: * Take capsules to achieve a total daily dose of 1000 mg of IPA or placebo: 500 mg every morning and 500 mg every evening for 14 days. * Visit the clinic at the beginning (day 1) and at the end (day 15) of the supplementation period to deliver blood, urine and fecal samples, have simple measurements performed, fulfil questionnaires and report any side effects.
CONDITIONS
Official Title
Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy women and men aged 18 to 65 years
- Mentally and physically able to participate
You will not qualify if you...
- Diagnosis of gut-, heart-, liver-, kidney- or immune-related disorders
- Use of antibiotics within the last month
- Pregnancy, lactation, or childbirth within the last five months
- Use of prescription medication
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Optic Neuritis Clinic, Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet-Glostrup
Glostrup Municipality, Denmark, 2600
Actively Recruiting
Research Team
M
Moschoula Passali, MSc, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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