Actively Recruiting
Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine
Led by University Hospital, Bordeaux · Updated on 2025-01-09
358
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
PRESSURE is a multicenter, prospective, randomized, open, blinded end-point assessed (PROBE) trial, that aims to evaluate the efficacy and safety of drug-induced hypertension using peripheral dilute norepinephrine, in patients with acute ischemic stroke in a perforating artery territory and experiencing early neurological deterioration.
CONDITIONS
Official Title
Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute ischemic stroke less than 72 hours old in a perforating artery area confirmed by brain MRI
- Early neurological worsening or fluctuations confirmed by a neurologist, defined by specific increases in NIH Stroke Scale scores
- Less than 6 hours between neurological worsening and study enrollment
- Age 18 years or older
- Women of childbearing potential must use effective contraception
- Must have health insurance coverage
You will not qualify if you...
- Modified Rankin Score greater than 3 before stroke
- Cannot have a brain MRI
- High risk of brain bleeding, including many cerebral microbleeds, certain brain conditions, or past brain hemorrhage
- Received intravenous clot-busting treatment less than 24 hours ago
- Need blood thinners in the first 7 days after enrollment
- Systolic blood pressure over 180 mmHg or mean arterial pressure 110 mmHg or higher at enrollment
- Large artery disease or other specified stroke causes
- Use of drugs that interact with norepinephrine such as monoamine oxidase inhibitors, certain antidepressants, or entacapone
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU de Bordeaux
Bordeaux, France
Actively Recruiting
Research Team
P
Pauline RENOU
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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