Actively Recruiting
Induced Pluripotent Stem Cells-derived Small Extracellular Vesicles May Promote Neurological Function and Improve Cognitive Impairment in Acute Ischemic Stroke Patients
Led by Hongmei Wang · Updated on 2025-08-28
40
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study primarily evaluates whether iEV nasal administration can improve neurological impairment and cognitive dysfunction in patients with acute cerebral infarction and cognitive impairment, and preliminarily explores its clinical efficacy.
CONDITIONS
Official Title
Induced Pluripotent Stem Cells-derived Small Extracellular Vesicles May Promote Neurological Function and Improve Cognitive Impairment in Acute Ischemic Stroke Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �38 years old.
- Diagnosed with acute ischemic stroke (AIS) according to WHO criteria.
- Stroke onset to enrollment time �3c 2 weeks with stable condition and able to cooperate with cognitive assessment.
- Cognitive impairment with a Montreal Cognitive Assessment (MoCA) score less than 26.
- Stroke lesions confirmed by cerebral MRI or CT scan.
- Voluntary participation with signed informed consent by patient or family members.
You will not qualify if you...
- Cognitive impairment diagnosed before the onset of AIS.
- Aphasia, hearing impairment, visual impairment, dysarthria, or other conditions preventing completion of neuropsychological assessments.
- History of mental illnesses such as depression, anxiety disorder, or schizophrenia.
- Severe diseases affecting heart, liver, lungs, kidneys, or other vital organs.
- Disturbed consciousness, history of long-term alcohol use, severe head trauma, or inability to cooperate with cognitive tests.
- Illiteracy.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Sixth People's Hospital
Shanghai, China, 200000
Actively Recruiting
Research Team
H
Hongmei Wang, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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