Actively Recruiting
Association of Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients: A Large-Scale Retrospective Cohort Analysis
Led by Zeliha Alicikus · Updated on 2026-04-14
4
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
Z
Zeliha Alicikus
Lead Sponsor
U
University of Florida
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the safety and effectiveness of different induction agents used for tracheal intubation in critically ill adult patients. This retrospective cohort study aims to identify which agents may minimize complications and mortality during intubation, a vital procedure to support breathing and prevent aspiration in emergency and intensive care settings. The study responds to the need for clearer evidence about the best induction agents, considering patient differences and treatment combinations. The study compares four main induction agents: Propofol, Midazolam, Etomidate, and Ketamine, which are commonly used in intensive care units. Clinical data about the use of these agents during intubation in surgical ICU patients will be collected and analyzed retrospectively. The study focuses on how each agent affects patient outcomes such as cardiovascular stability during intubation and early mortality. Participants are critically ill adults admitted to a surgical ICU who received one of the studied induction agents and have complete clinical records. Researchers will measure outcomes including all-cause mortality within seven days after intubation, cardiovascular collapse around the time of intubation, and overall clinical progression. The study will use hospital records to assess these outcomes, and participation involves a review of existing medical data without additional procedures.
CONDITIONS
Brief Title
Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Admission to the surgical ICU for critical care
- Administration of one of the studied induction agents (Propofol, Midazolam, Etomidate, Ketamine)
- Availability of complete clinical data
You will not qualify if you...
- Age under 18 years
- No documented administration of an induction agent
- Incomplete or missing medical records
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of hospitalization following intubation
Participants who undergo routine care are observed, and clinical data related to the induction agent used for intubation in the ICU are collected throughout hospitalization.
Data collected during hospitalization as per routine care
Duration - Up to 7 days after intubation
Participants are monitored for outcomes including all-cause mortality up to 7 days following tracheal intubation.
Follow-up assessments up to day 7
Trial Site Locations
Total: 1 location
1
UF Health Jacksonville (Shands Hospital)
Jacksonville, Florida, United States, 32209
Actively Recruiting
Research Team
T
TOLGA SARAÇOĞLU, Prof,MD
T
Tolga Saraçoğlu, Asc Prof,MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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