Actively Recruiting
Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2023-08-08
100
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to elucidate the regression effects of neoadjuvant chemotherapy combined with immunotherapy and adjuvant therapy in locally advanced MSS colon cancer.
CONDITIONS
Official Title
Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years old
- Pathologically diagnosed MSS or pMMR-type colon adenocarcinoma
- Tumor lower edge more than 12 cm from the anus and not directly palpable during rectal exam
- Enhanced CT stage T3/4 or T1-4N+ without multiple primary tumors or distant metastasis
- Life expectancy over 1 year
- First diagnosis with no prior anti-tumor treatment and no chemotherapy contraindications
- Able to understand and willing to provide written informed consent
You will not qualify if you...
- Refusal to participate in the study
- Multifocal colorectal cancer
- History of malignant tumors except basal cell carcinoma, papillary thyroid carcinoma, and in situ cancers
- Inability to tolerate chemotherapy, including bone marrow suppression
- Acute exacerbation of major organ diseases or severe acute infections, ASA score > 3
- Mental disorders, illiteracy, or language barriers preventing study understanding
- Tumor obstruction or high risk of obstruction, bleeding, or perforation
- Peripheral sensory neuropathy preventing oxaliplatin chemotherapy
- Pregnancy or lactation
- Inability to undergo enhanced CT or requiring glucocorticoid therapy
- Use of glucocorticoids for more than 3 days within 1 month before consent
- Tumor lower border below sacrococcygeal promontory to pubic symphysis line on mid-sagittal CT or MRI
- Other conditions deemed unsuitable by the researcher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
L
Li Jun, MD
CONTACT
J
Jiao Yurong
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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