Actively Recruiting
Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide
Led by Danish Headache Center · Updated on 2025-08-06
21
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Calcitonin gene-related peptide (CGRP) is a key neuropeptide in migraine pathophysiology and treatment. This study investigates whether CGRP administration can trigger aura in individuals with a diagnosis of migraine with aura.
CONDITIONS
Official Title
Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 65 years at screening
- History of migraine with aura for 12 months or more according to ICHD-3 criteria
- At least 1 monthly day with aura on average across the three months before screening
- Signed informed consent before any study procedures
You will not qualify if you...
- Any primary or secondary headache disorder other than migraine with aura, migraine without aura, chronic migraine, or episodic tension-type headache
- Any other significant medical condition that may risk safety or interfere with study participation
- Risk of self-harm or harm to others based on past behavior
- Positive pregnancy test in women of childbearing potential during study visits
- Any cardiovascular or cerebrovascular disease
- High blood pressure (systolic 6150 mmHg or diastolic 6100 mmHg) before infusion
- Low blood pressure (systolic 490 mmHg or diastolic 450 mmHg)
- Changes in prophylactic medication dosing within 2 months before study
- Use of acute headache medications within 48 hours before infusion
- Headache or aura occurring within 48 hours before infusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rigshospitalet Glostrup
Glostrup Municipality, Denmark, 2600
Actively Recruiting
Research Team
H
Haidar Al-Khazali, MD
CONTACT
H
Hakan Ashina, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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