Actively Recruiting
Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions
Led by M.D. Anderson Cancer Center · Updated on 2026-03-05
208
Participants Needed
1
Research Sites
560 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE). Indwelling pleural catheters (IPCs) are commonly used to treat pleural effusions (build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat pleural effusions. The goal of this clinical research study is to learn if adding doxycycline to the use of an IPC can lead to shorter treatment times with IPCs.
CONDITIONS
Official Title
Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Outpatients with malignant pleural effusion undergoing indwelling pleural catheter placement
- Ability to provide informed consent and answer health-related questions such as the Short-Form Six-Dimension health index and Borg score
- Inpatients expected to be discharged within 5 days after receiving an indwelling pleural catheter
You will not qualify if you...
- Patients undergoing pleurodesis for non-cancerous conditions such as spontaneous pneumothorax
- Unable or unwilling to provide informed consent
- Unable to complete phone call and clinical follow-up at MD Anderson Cancer Center
- Pregnancy
- Previous intrapleural therapy for malignant pleural effusion on the same side
- Eastern Cooperative Oncology Group (ECOG) performance status of 4 with life expectancy of 2 weeks or less
- Allergy to doxycycline
- Extensive fluid loculations, hydropneumothorax, or other contraindications to pleurodesis
- Chylous effusions related to malignant disease
AI-Screening
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Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
D
David Ost
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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