Short-Term Effects of Prone Positioning After Surfactant Treatment in Infants With Severe Acute Respiratory Distress Syndrome

What this Trial Is About

This research investigates the short-term effects of prone positioning on infants with infection-associated severe acute respiratory distress syndrome ARDS. The study focuses on infants who are mechanically ventilated and have received surfactant treatment. The main goal is to compare oxygenation parameters and lung function using electrical impedance tomography EIT and lung ultrasonography LUS between infants placed in prone versus supine positions. Participants are randomly assigned to one of two groups one group is turned to the prone position immediately after surfactant administration, staying prone for 6 hours before returning to supine for assessment the other group remains in the supine position throughout. Both groups undergo EIT and LUS measurements after 6 hours to evaluate lung aeration and function. During the study, infants are monitored for changes in oxygenation saturation index and lung ultrasound scores from baseline to 6 hours post-intervention. Researchers also assess the distribution of end-expiratory lung volume and tidal volume using EIT. Parental consent is required, and infants must be intubated and mechanically ventilated. The study is conducted at a pediatric or neonatal intensive care unit and is expected to complete by the end of 2027.

Infants With Severe Acute Respiratory Distress Syndrome: The Prone Trial