Actively Recruiting
The Predictive Value of the Inferior Vena Cava Collapsibility Index for Intradialytic Hypotension: A Prospective Multicenter Observational Study
Led by First Affiliated Hospital of Wannan Medical College · Updated on 2025-06-24
188
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Wannan Medical College
Lead Sponsor
W
Wuhu County Traditional Chinese Medicine Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the ability of the Inferior Vena Cava Collapsibility Index (IVCCI), along with maximum and minimum diameters of the Inferior Vena Cava (IVCmax and IVCmin), to predict intradialytic hypotension in adults with end-stage renal disease (ESRD) who are undergoing maintenance hemodialysis. This multicenter, prospective observational study aims to find a simple, non-invasive method to personalize dialysis management and reduce episodes of low blood pressure during dialysis sessions. Participants will have ultrasound measurements of IVCCI, IVCmax, and IVCmin taken once, exactly one hour after starting their dialysis session. Blood pressure will be monitored continuously during the dialysis procedure. No experimental treatments will be given, as this study observes the relationship between ultrasound measurements and blood pressure changes in patients already receiving maintenance hemodialysis. During the study, adults aged 18 to 80 with ESRD on regular hemodialysis for at least three months will be monitored at several hospitals. Researchers will assess how well the ultrasound measurements predict intradialytic hypotension by analyzing sensitivity, specificity, and optimal cutoff values. The study includes blood pressure monitoring, ultrasound scans, and collection of clinical data to improve understanding and safety of dialysis treatments over one dialysis session lasting up to four hours.
CONDITIONS
Brief Title
Inferior Vena Cava Collapsibility Index and Intradialytic Hypotension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with end-stage renal disease (ESRD)
- Undergoing regular hemodialysis for at least three months
You will not qualify if you...
- Pregnant or breastfeeding women
- Hemodynamically unstable patients or those requiring vasopressor support
- Patients with severe cardiac conditions, including congestive heart failure classified as NYHA Class III-IV or severe valvular disease
- Patients with known allergies to dialysis filters
- Dialysis sessions terminated for reasons unrelated to hypotension (e.g., technical issues, patient request)
- Patients who withdraw informed consent during the study
- Use of antihypertensive medications during dialysis sessions
- Inability to undergo ultrasound assessment due to factors such as severe obesity or wounds obstructing access
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to one dialysis session (4 hours)
Participants who undergo routine maintenance hemodialysis are observed with non-invasive ultrasound measurements of the Inferior Vena Cava Collapsibility Index and routine blood pressure monitoring before and during dialysis sessions.
1 hemodialysis session visit (in-person)
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)
Wuhu, Anhui, China, 241000
Actively Recruiting
Research Team
Q
Qiancheng Xu
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here