Correlation of Inflammation Severity With Pulmonary Gas Exchange and MiRNA-126 in Trauma Patients

What this Trial Is About

This research investigates the relationship between the severity of inflammation and lung function impairment in patients who have experienced trauma. It focuses on how markers of inflammation, such as C-reactive protein, procalcitonin, IL-6, and others, relate to lung injury risk and gas exchange problems. The study also explores the role of circulating microRNA-126 (miR-126) in maintaining lung barrier integrity and its potential in reflecting inflammatory burden after trauma. The study observes trauma patients admitted to intensive care units, including those who develop acute respiratory distress syndrome (ARDS) and those who do not, alongside a control group of healthy volunteers. Researchers collect blood samples, perform ultrasounds to assess vascular function, and measure clinical parameters like blood pressure and heart rate over the first three days of ICU admission. These assessments aim to correlate laboratory inflammation markers, imaging findings, and pulmonary gas-exchange measurements. Participants will be monitored closely for at least three days in intensive care, during which various blood tests, arterial blood gases, and ultrasound imaging are performed. The study measures the primary outcome as the correlation between serum miR-126 levels and lung injury severity in the initial ICU period. Secondary outcomes include levels of IL-6, syndecan, and flow-mediated dilation assessed by ultrasound. The findings may help identify biomarkers useful for predicting lung complications and guiding care after severe trauma.

Inflammation Severity and miRNA-126 in Trauma