Effect of Preoperative Inflammatory Biomarkers on Postoperative Delirium in Children Undergoing Circumcision

What this Trial Is About

Postoperative delirium can occur in children after general anesthesia, even following short procedures like circumcision. This observational study evaluates the link between preoperative inflammatory markers and postoperative delirium in children aged 2 to 12 years undergoing elective circumcision under general anesthesia. The study aims to find simple blood-based markers that might help predict the risk of delirium after surgery in pediatric patients. Blood samples will be taken before surgery to measure inflammatory biomarkers such as neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, monocyte-to-lymphocyte ratio, and systemic inflammation response index. These markers will be analyzed in relation to the development and severity of delirium assessed within 2 hours after surgery using the Pediatric Anesthesia Emergence Delirium (PAED) scale. No experimental drugs or devices will be used; all procedures follow standard care protocols. Participants will be monitored in the post-anesthesia care unit, where delirium will be assessed shortly after surgery. Researchers will review blood test results and delirium scores to understand the relationship between inflammation and delirium severity. The main outcome measured is the incidence of delirium within 2 hours after surgery, with secondary outcomes focusing on the correlation between biomarker levels and delirium severity. The study is expected to finish by July 2026.

Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision