Actively Recruiting
Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision
Led by Ankara Etlik City Hospital · Updated on 2026-02-20
140
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative delirium may occur in children after general anesthesia, even following short procedures such as circumcision. Preoperative systemic inflammation has been associated with postoperative delirium in adults, but data in pediatric patients are limited. This prospective observational study aims to evaluate the association between preoperative inflammatory biomarkers and postoperative delirium in children aged 2-12 years undergoing elective circumcision under general anesthesia. Inflammatory biomarkers derived from routine complete blood count parameters, including NLR, PLR, MLR, SII, and SIRI, will be analyzed. Postoperative delirium will be assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale in the post-anesthesia care unit. The relationship between inflammatory biomarkers and delirium development and severity will be evaluated. This study seeks to identify simple preoperative markers that may help predict postoperative delirium risk in pediatric patients.
CONDITIONS
Official Title
Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 2-12 years
- Scheduled for elective circumcision under general anesthesia
- Classified as ASA physical status I-II
- Written informed consent from parents or legal guardians
- Age-appropriate verbal assent obtained from the child
- Anesthesia and surgery performed according to standard institutional protocols
You will not qualify if you...
- History of neurological or psychiatric disorders (e.g., epilepsy, developmental delay, autism spectrum disorder, anxiety disorders)
- Classified as ASA physical status III-IV
- Incomplete preoperative laboratory data or hematological/hormonal disorders affecting inflammatory parameters
- Excessive sedation after premedication or incomplete preoperative assessment
- Protocol deviations during surgery or anesthesia (e.g., additional medications, prolonged surgery, procedural changes due to complications)
- Parents or legal guardians do not provide consent or decline participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ankara Etlik City Hospital
Altındağ, Ankara, Turkey (Türkiye)
Actively Recruiting
Research Team
A
Ahmet Murat Gül
CONTACT
A
Aslı Dönmez
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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