Actively Recruiting
Inflammatory faCtors AfteR acUte Ischemic Stroke
Led by Martin Dichgans · Updated on 2025-04-04
36
Participants Needed
2
Research Sites
391 weeks
Total Duration
On this page
Sponsors
M
Martin Dichgans
Lead Sponsor
U
Universitätsklinikum Hamburg-Eppendorf
Collaborating Sponsor
AI-Summary
What this Trial Is About
ICARUS is an interventional single-centre hospital-based cohort study in patients admitted to the stroke unit with an acute ischemic stroke. The aims of the study are to i) define the characteristics and determinants of microglial activation after human stroke, and ii) assess the correlation of microglial activation with circulating inflammatory markers, structural brain changes on neuroimaging, and neurological outcomes. ICARUS involves serial TSPO-PET imaging along with serial MRI, immune cell profiling in blood, and both clinical and laboratory assessments in 36 patients with acute ischemic stroke caused by a cortical (N=18) or strictly subcortical (N=18) infarct. In a substudy, the investigators will include 10 independently recruited patients with acute ischemic stroke to assess MRI arterial spin labelling (ASL) sequences as a marker for perfusion measurement of the TSPO tracer.
CONDITIONS
Official Title
Inflammatory faCtors AfteR acUte Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 years or older
- Acute ischemic stroke within 72 hours confirmed by MRI showing a cortical or strictly subcortical infarct
- Ability to provide written informed consent before participating
- Willingness to take part in all study assessments including follow-up visits
You will not qualify if you...
- Unable or unwilling to provide written consent
- History of previous stroke, multiple infarcts, or infratentorial infarcts affecting brain stem or cerebellum
- Known diseases of the central nervous system other than stroke
- Use of immunomodulatory treatments within 3 months before stroke
- Chronic inflammatory diseases
- Infectious diseases within 7 days before stroke
- Conditions that interfere with follow-up such as end-stage cancer
- Contraindications for MRI or PET scans (e.g., pacemaker, aneurysm clip, cochlear implant)
- Radiation exposure exceeding 10 mSv per year
- Pregnant or breastfeeding women
- Participation in another clinical trial
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Insitute for Stroke and Dementia Research
Munich, Germany, Germany, 81377
Actively Recruiting
2
Department of Nuclear Medicine
Munich, Germany, 81377
Actively Recruiting
Research Team
M
Martin Dichgans, Prof.
CONTACT
A
Anna Kopczak, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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